TSHR-CAR/Foxp3 mRNA诱导的Treg细胞靶向治疗小鼠Graves病的机制研究

国家自然科学基金青年项目

主持

基于机器学习算法的T细胞受体模型预测Graves甲亢患者眼病的发生

陕西省青年科技新星

主持

西北地区慢病防控科技综合示范研究

国家重点研发计划

研究骨干

糖尿病信息化管理平台与传播体系的创建

国家重点研发计划

研究骨干

基于机器学习算法的T细胞受体模型预测Graves甲亢患者眼病的发生

中央高校基本科研业务费

主持

应用T细胞受体模型预测Graves甲亢患者眼病的发生

中国博士后基金面上项目

主持

TSHR-Foxp3 mRNA靶向治疗小鼠Graves病

陕西省自然科学基金

主持

甲巯咪唑联合雷帕霉素对难治性Graves甲亢患者临床治疗效果的研究

西安交通大学第一附属医院临床研究基金面上项目

主持

TSHR-CAR/Foxp3 mRNA诱导的Treg细胞靶向治疗小鼠Graves病

西安交通大学医学“基础-临床”融合创新项目

主持

基于医工交叉的甲亢诊疗新技术体系研究与开发

陕西省重点研发项目

——关键核心技术攻关-社会发展领域

主持

三秦英才特殊支持计划青年拔尖人才

三秦英才特殊支持计划青年拔尖人才

主持

西罗莫司联合甲强龙与麦考酚酸酯联合甲强龙在难治性甲状腺相关眼病的疗效及安全性比较研究

一附院临床研究项目

主持

免疫与临床医学研究团队

2024年交大青年创新团队

主持

A   novel CD4+CTL subtype characterized by chemotaxis and inflammation is   involved in the pathogenesis of Graves' orbitopathy. Cellular & Molecular Immunology. 2021 Mar;18(3):735-745

Yue Wang, Ziyi Chen, Tingjie Wang, Hui Guo, Yufeng Liu, Ningxin Dang,   Shiqian Hu, Liping Wu, Chengsheng Zhang, Kai Ye*, Bingyin Shi*

2021

24.1

53

Selenium deficiency is linearly associated   with hypoglycemia in healthy adults. Redox Biology. 2020 Oct;37:101709

Yue Wang , Rijntjes Eddy,   Qian Wu, Hongjun Lv; Chuqi Gao; Bingyin Shi *, Lutz Schomburg*

2020

13.1

31

Rapamycin improves Graves’ orbitopathy by   suppressing CD4+ cytotoxic T   lymphocytes. JCI Insight. 2022 Dec 29;e160377

Meng Zhang, Kelvin Kl Chong, Zi-Yi Chen, Hui   Guo, Yu-Feng Liu, Yong-Yong Kang, Yang-Jun Li, Ting-Ting Shi, Kenneth Ka Hei   Lai, Ming-Qian He, Kai Ye, George J Kahaly, Bing-Yin Shi, Yue Wang

2023

8

23

Predicting the early risk of ophthalmopathy in   Graves’ disease patients using TCR repertoire. Clinical and Translational Medicine. 2020 Nov;10(7):e218

Yue Wang, Yufeng Liu,   Xiaofei Yang, Hui Guo, Jiadong Lin, Jinkui Yang, Mingqian He, Jingya Wang,   Xiaomei Liu, Tingting Shi, Liping Wu, Chengsheng Zhang, Kai Ye*, Bingyin   Shi*.

2020

10.6

3

VEGF-A enhances the cytotoxic function of CD4+   cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway.   Journal of Translational Medicine. 2023

Ziyi Chen; Meng Zhang; Yufeng Liu; Zhe Chen;   Ling Wang; Wenjuan Wang; Jincheng Wang; Mingqian He; Bingyin Shi; Yue Wang*.

2023

7.5

10

A preclinical state of Graves' ophthalmopathy   characterized by hypoxia of T-cells identified via multi-omics analysis. Journal of Clinical Endocrinology &   Metabolism. 2025 2025 Apr 11

Zhang, Meng; Qi, Xin; Zhou,   Xingchen; Liu, Yufeng; He,   Mingqian; Wang,   Jingya; Wang, Ling; Chen, Ziyi; Li, Simo; Chen, Yu; Sun, Yushi; Guo, Hui; Yang, Jin; Shi,   Bingyin; Wang, Yue*

2025

5.8

Negative association between serum calcium and

glucocorticoid-induced hypertension in   thyroid-associated ophthalmopathy patients treated with methylprednisolone. Frontiers in   Endocrinology.

2025

5.2

Hyperlipidemia and apolipoprotein E are associated   with intraocular pressure of thyroid-associated ophthalmopathy in a Chinese   population: a cross-sectional study. Frontiers in   Endocrinology. 2024 Nov   28:15:1484343

Yu Chen, Xin Qi, Jingya Wang, Huayang Xu,   Yushi Sun, Ling Wang, Xingchen Zhou, Mingqian He, Jiarui Zhao, Jinbo Zhang,   Hairong He, Hui Guo, Bingyin Shi, Yue Wang*, Meng Zhang

2024

5.2

A Promising Mouse   Model of Graves’ Orbitopathy Induced by Adenovirus Expressing Thyrotropin   Receptor A Subunit. Thyroid. 2021 Apr;31(4):638-648

Meng Zhang, Xi   Ding, Li-ping Wu, Ming-qian He, Zi-yi Chen, Bing-yin Shi*, Yue Wang*.

2021

6.6

24

Role of Selenium   Intake for Risk and Development of Hyperthyroidism. Journal of Clinical Endocrinology & Metabolism. 2019   Feb 1;104(2):568-580

Yue Wang, Fengyi Zhao, Rijntjes Eddy, Liping Wu, Qian Wu, Jing Sui,   Yufeng Liu, Meng Zhang, Mingqian He, Pu Chen, Shiqian Hu, Peng Hou, Lutz Schomburg, Bingyin Shi*.

2019

5.8

27

Decreased Treg   cell and TCR expansion are involved in long-lasting Graves' disease. Frontiers in Endocrinology. 2021 Apr 12;12:632492

Ziyi Chen, Yufeng   Liu, Shiqian Hu, Meng Zhang, Bingyin Shi*, Yue Wang*.

2021

5.2

14

Leptin receptor   is a key gene involved in the immunopathogenesis of thyroid-associated   ophthalmopathy. Journal of Cellular and Molecular Medicine. 2021   Jun;25(12):5799-5810

Ziyi Chen, Zhe   Chen, Jingya Wang, Meng Zhang, Xiaofei Wang, Deji Cuomu, Bingyin Shi*, Yue Wang*.

2021

5.3

4

Time-restricted   eating with or without low-carbohydrate diet reduces visceral fat and improves   metabolic syndrome: A randomized trial. Cell Rep Med. 2022 Oct   18;3(10):100777.

Mingqian He,   Jingya Wang, Qian Liang, Meng Li, Hui Guo, Yue Wang, Cuomu Deji, Jing Sui, Ya-Wen Wang, Yufeng Liu, Yixuan   Zheng, Buyue Qian, Huaixi Chen, Mao Ma, Shi Su, Hui Geng, Wen-Xu Zhou,   Xiaoxiao Guo, Wen-Zhi Zhu, Meng Zhang, Ziyi Chen, Patrick C N Rensen,   Chi-Chung Hui , Yanan Wang, Bingyin Shi

2022

14.3

19

Increased   Incidence of Hashimoto Thyroiditis in Selenium Deficiency: A Prospective   6-Year Cohort Study. Journal of Clinical Endocrinology & Metabolism. 2022   Aug 18;107(9):e3603-e3611

Qian Wu, Yue Wang, Ping Chen, Jing Wei,   Hongjun Lv, Si Wang, Yajun Wu, Xuan Zhao, Xiaogang Peng, Eddy Rijntjes, Youfa   Wang, Lutz Schomburg, Bingyin Shi*

2022

5.8

23

Sirolimus versus   mycophenolate mofetil for triple immunosuppression in thyroid eye disease patients with recent-onset intractable diplopia: A prospective comparative case   series. Clin Exp  Ophthalmol  . 2023   Nov;51(8):878-881.

Kenneth K H Lai, Yue   Wang, Chi Pui Pang , Kelvin K L Chong

2023

4.9

5

Time-restricted   eating with or without a   low-carbohydrate diet improved myocardial status and   thyroid function in individuals with metabolic   syndrome: secondary analysis of a randomized   clinical trial. BMC Med . 2024 Sep   4;22(1):362.

Yixuan Zheng,   Jingya Wang,, Mengmeng Liu, Xingchen Zhou, Xiaoying Lin, Qian Liang, Jing   Yang, Meng Zhang, Ziyi Chen, Meng Li, Yue Wang, Jing Sui, Wei   Qiang  Hui Guo, Bingyin Shi , Mingqian   He

2024

7

Effects of time-restricted   eating and low-carbohydrate diet on psychosocial health and appetite in   individuals with metabolic syndrome: A secondary analysis of a randomized   controlled trial. Clin Nutr. 2024 Aug 30;43(10):2316-2324.

Yixuan Zheng, Xin   Wang, Jingya Wang , Jing Yang, Ting Wang, Qian Li , Wenzhi Zhu , Yue Wang,   Jing Sui, Wei Qiang, Hui Guo, Yanan Wang, Bingyin Shi , Mingqian He

2024

6.6

The proportion of   peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease   patients: a meta-analysis. Endocrine Journal. 2020 Mar 28;67(3):317-326

Ziyi Chen, Yue Wang, Xi Ding, Meng Zhang,   Mingqian He, Yang Zhao, Shiqian Hu, Fengyi Zhao, Jingya Wang, Baosong Xie,   Bingyin Shi*.

2020

2

17

Graves'   Orbitopathy Models: Valuable Tools for Exploring Pathogenesis and Treatment.Horm   Metab Res.2023 Nov;55(11):745-751

Ling Wang, Meng   Zhang, Yue Wang, Bingyin Shi

2023

2.2

0

Dihydrotestosterone   regulates oxidative stress and immunosuppressive cytokines in a female BALB/c   mouse model of Graves' disease. Autoimmunity. 2019 May;52(3):117-125

Fengyi Zhao,   Liping Wu, Yue Wang, Lianye Liu,   Fei Yang, Yunshi Sun, Xiang Jiao, Lingyu Bao, Pu Chen, Qian Liang, Bingyin   Shi*

2019

3.5

7

Factors   associated with the efficacy of intravenous methylprednisolone in moderate‐to‐severe and active thyroid‐associated ophthalmopathy: A single‐centre retrospective study. Clinical Endocrinology. 2019   Jan;90(1):175-183

Shiqian Hu, Yue Wang, Mingqian He, Meng Zhang, Xi   Ding, Bingyin Shi*.

2018

3.2

7

The Potential   Markers Involved in Newly Diagnosed Graves' Disease and the Development of   Active Graves' Orbitopathy. Cytokine. 2020 Mar;127:154998

Mingqian He , Yue Wang, Jingya Wang, Jing Sui, Xi   Ding, Ziyi Chen, Meng Zhang, Yang Zhao, Baosong Xie, Bingyin Shi*.

2020

3.8

6