消化系肿瘤分子信号调控网络与诊疗转化研究

（1）2022-01 至 今，西安交通大学第一附属医院消化内科，副主任、研究员、副主任医师

（2）2021-01 至 今，西安交通大学第一附属医院消化内科，副主任医师

（3）2016-11 至 2021-12，西安交通大学第一附属医院消化内科，副研究员

（4）2015-10 至 2016-10，肿瘤生物学国家重点实验，副教授

（5）2011-06 至 2015-10，第四军医大学第一附属医院消化外科，主治医师

（6）2011-09 至 2012-03，香港大学医学院玛丽医院消化外科，助理临床研究员

（7）2005-06 至 2011-06，第四军医大学第一附属医院消化外科，医师

（1）国家自然科学基金委员会，联合基金项目，U2230112，强激光驱动辐射源在精准放射医疗领域的分子靶向作用机理和创新应用，2023-01-01至2025-12-31，49万元，主持

（2）国家自然科学基金委员会，面上项目，82173337，Notch4通过调控LUNAR1 m6A修饰拮抗Notch1在结肠癌侵袭转移中的作用机制研究，2022-01-01至2025-12-31，54.7万元，主持

（3）国家自然科学基金委员会，面上项目，81672460，NDRG4-NF-κB反馈环路在结直肠癌中对Notch信号受体间调控的作用和机制， 2017-01-01至 2020-12-31，57万元，主持

（4）国家自然科学基金委员会，青年项目，81201927，结直肠癌中NDRG2参与Notch2对Notch1抑制调控的作用及机制研究，2013-01-01 – 2015-12-31，24万元，主持

（5）中央高校基本科研业务费，消化系肿瘤交叉创新团队，2023-01-01–2025-12-31，75万元，主持

（6）陕西省创新人才推进计划，2022TD-58，消化系肿瘤精准诊疗研究与临床转化创新团队，2022-01-01–2024-12-31，50万元，主持

1.Jiahui He, Zixi Zhang, Yutong Yang, Fenggang Ren, Jipeng Li, Shaojun Zhu, Feng Ma, Rongqian Wu, Yi Lv, Gang He, Baolin Guo, Dake Chu. Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing. Nano-Micro Letters. 2021, February 27.

2.Zhang, Zixi; Li, Gai; Qiu, He; Yang, Jingyi; Bu, Xin; Zhu, Shaojun; Zheng, Jianyong; Dang, Chengxue; Wang, Weizhong; Chu, Dake. The Novel Notch-induced Long Noncoding RNA LUNAR1 Determines the Proliferation and Prognosis of Colorectal Cancer. Scientific Reports, 2019, 9(1): 0-19915.

3.Zhang Zixi; Bu Xin; Yang Jingyi; Zhu Shaojun; He Shuixiang; Zheng Jianyong; Wang Weizhong; Chu Dake. NOTCH4 regulates colorectal cancer proliferation, invasiveness, and determines clinical outcome of patients. Journal of Cellular Physiology, 2018.10, 233(10): 6975~6985

4.Zhang, Zixi; She, Junjun; Yang, Jingyi; Bu, Xin; Ji, Gang; Zhu, Shaojun; He, Shuixiang; Chu, Dake. NDRG4 in gastric cancer determines tumor cell proliferation and clinical outcome. Molecular Carcinogenesis, 2018.06, 57(6): 762~771

5.Chu, Dake; Zhou, Yi; Zhang, Zixi; Li, Yuming; Li, Jipeng; Zheng, Jianyong; Zhang, Hongwei; Zhao, Qingchuan; Wang, Weizhong; Wang, Rui'an; Ji, Gang. Notch1 Expression, Which Is Related to p65 Status, Is an Independent Predictor of Prognosis in Colorectal Cancer. Clinical Cancer Research, 2011.9.1, 17(17): 5686~5694

6.Chu, D; Zhang, Z; Zhou, Y; Wang, W; Li, Y; Zhang, H; Dong, G; Zhao, Q; Ji, G. Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer. Annals of Oncology, 2011.11, 22(11): 2440~2447

7.Chu, Dake; Li, Yunming; Wang, Weizhong; Zhao, Qingchuan; Li, Jipeng; Lu, Yuanyuan; Li, Mengbin; Dong, Guanglong; Zhang, Hongwei; Xie, Huahong; Ji, Gang. High Level of Notch1 Protein is Associated with Poor Overall Survival in Colorectal Cancer. Annals of Surgical Oncology, 2010.5, 17(5): 1337~1342

8.Chu, Dake; Zhao, Zhengwei; Zhou, Yi; Li, Yunming; Li, Jipeng; Zheng, Jianyong; Zhao, Qingchuan; Wang, Weizhong. Matrix Metalloproteinase-9 Is Associated with Relapse and Prognosis of Patients with Colorectal Cancer. Annals of Surgical Oncology, 2012.1, 19(1): 318~325

9.Chu, Dake; Zhang, Zixi; Li, Yunming; Wu, Lin; Zhang, Jing; Wang, Weizhong; Zhang, Jian. Prediction of Colorectal Cancer Relapse and Prognosis by Tissue mRNA Levels of NDRG2. Molecular Cancer Therapeutics, 2011.1, 10(1): 47~56

10.Chu, Dake; Zhang, Zixi; Li, Yunming; Zheng, Jianyong; Dong, Guanglong; Wang, Weizhong; Ji, Gang. Matrix metalloproteinase-9 is associated with disease-free survival and overall survival in patients with gastric cancer. International Journal of Cancer, 2011.8.15, 129(4): 887~895

11.Chu, Dake; Zheng, Jianyong; Wang, Weizhong; Zhao, Qingchuan; Li, Yunming; Li, Jipeng; Xie, Huahong; Zhang, Hongwei; Dong, Guanglong; Xu, Chunsheng; Li, Mengbin; Chen, Dongli; Ji, Gang. Notch2 Expression Is Decreased in Colorectal Cancer and Related to Tumor Differentiation Status   Annals of Surgical Oncology, 2009.12, 16(12): 3259~3266

12.Chu, Dake; Wang, Weizhong; Xie, Huahong; Li, Yunming; Dong, Guanglong; Xu, Chunsheng; Chen, Dongli; Zheng, Jianyong; Li, Mengbin; Lu, Zifan; Ji, Gang. Notch1 Expression in Colorectal Carcinoma Determines Tumor Differentiation Status. Journal of Gastrointestinal Surgery, 2009.2.2, 13(2): 253~260

发明专利：

一种离子型紫罗精类化合物及其光动力治疗应用，2021

一种肝胆科用取石器，2019

一类硼氮杂苯并联噻吩衍生物、共轭高分子聚合物及其制备方法和氟离子检测应用，2020

一类碳硼烷紫罗精衍生物及其金属超分子聚合物、合成方法和应用，2021

科技奖励：

陕西省科学技术二等奖

中华医学科技奖青年科技奖

教育部高等学校科学研究优秀成果奖

陕西省重点科技创新团队带头人

陕西省青年科技新星