1.噬菌体入侵与细菌耐药机制研究

2.噬菌体库建立与抗感染治疗

3.感染性疾病的分子诊断与治疗

教育经历：

1994年 华西医科大学医学学士学位

2000年 西安交通大学医学硕士学位

2013年 西安交通大学医学博士学位

2018年4月 美国Johns Hopkins University学习

工作经历：

1994.7-2001.6西安医科大学第一附属医院检验科任检验师

2001.6-2008.7西安交大第一附属医院检验科任主管检验师

2008.7-2014.12西安交大第一附属医院检验科任副主任技师

2014.1-2021.12 西安交大第一附属医院检验科任主任技师，副主任

2017.3-至今西交大第一附属医院生物样本信息资源中心主任

1.国家自然科学基金：基于噬菌体抑菌新机制构建作用于耐药金黄色葡萄球菌DNA聚合酶β亚基的抗菌肽（项目号：82272377），2023.1.1-2026.12.31,52万元（主持）

2.国家自然科学基金：融合蛋白质转导域的抗HBV核心蛋白穿膜抗体细胞内靶向抗病毒作用研究（项目号：81101260），2012.1-2014.12，22万元（主持）

3.陕西省重点研发计划-新药创制及医疗器械关键技术创新链（群）项目：靶向HBV核心蛋白的微小穿膜抗体抗病毒药物关键技术的研究（项目号：2019ZDLSF03-02）2019.6.1 2023.5.31，70万元（主持）

4.生物安全关键技术研发重点专项：中国人类遗传资源样本库建设项目之“华西地区中国人类遗传资源样本库集群建设”子课题（项目号：2016YFC1201705）2016.7-2018.12，子课题经费65万元（子课题负责人）

5.国家“重大新药创制”科技重大专项：西北地区恶性肿瘤新药临床评价示范性技术平台建设项目（项目号：2020ZX09201-020）2020.1-2020.12，参与（47万元）

近五年发表的一作和通讯作者的文章

1.     Peipei Zhang^#, Xiaohui Zhao^#, Yawen Wang^#, Ke Du, Zhihao Wang, Jianfeng Yu, Gang Chang, Steve Matthews , Hongliang Wang* , Bing Liu*.(2022). Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins. Proc Natl Acad Sci U S A. 119(9):e2116278119.

2.     Bing Liu ^#*,, Shanshan Li ^#, Yang Liu ^#, Huan Chen,  Zhenyue Hu,  Zhihao Wang,  Yimin Zhao, Lei Zhang,  Biyun Ma,  Hongliang Wang,  Steve Matthews,  Yawen Wang*,, Kaiming Zhang*,. Bacteriophage Twort protein Gp168 is a β-clamp inhibitor by occupying the DNA sliding channel. Nucleic Acids Research, 2021 Oct 6;gkab875. 

3.     Li J. ^#, Gao J.,^# Li N., Wang,Y.* (2021). Distribution of human papillomavirus genotypes in western China and their association with cervical cancer and precancerous lesions. Archives of Virology, 166:853–862.

4.     Wang, F., Wang, X., Li, N., Liu, J., Zhang, L., Hui, L., Feng, A., Wang, Z., & Wang, Y.* (2021). Prolonged unfolded protein reaction is involved in the induction of chronic myeloid leukemia cell death upon oprozomib treatment. Cancer science, 112(1), 133–143. 

5.     Zhang, K., Wang, Z., Chang, G., Wang, H., Wang, Y.*, & Liu, B*. (2020). Resonance assignments of bacteriophage T4 Y04L protein. Biomolecular NMR assignments, 14(1), 51–54. （IF：0.765）

6.     Hu, Y., Chen, T., Liu, M., Zhang, L., Wang, F., Zhao, S., Liu, H., Xia, H., Wang, Y.*, & Li, L*. (2020). Positive detection of SARS-CoV-2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non-conjunctivitis COVID-19 patient with obstruction of common lacrimal duct. Acta ophthalmologica, 98(8), 859–863.

7.     Zhao, S., Zhang, K., Jiang, S., Liu,Zhi., Wang Zhi., Wang, Y.*, & Liu, B*. (2019). Resonance assignments of sigma factor S binding protein Crl from Escherichia coli.. Biomolecular NMR assignments, 13(1), 223-226.

8.     Li, Y., Liu, Z., Hui, L., Liu, X., Feng, A., Wang, W., Zhang, L., Li, N., Zhou, G., Wang, Q., Han, Q., Lv, Y., Wang, Q., Yang, G., & Wang, Y. * (2017). Transbody against virus core protein potently inhibits hepadnavirus replication in vivo: evidence from a duck model of hepatitis B virus. British journal of pharmacology, 174(14), 2261–2272.

9.     Wang, Y., Li, Y., Li, N., Zhu, Q., Hui, L., Liu, X., Han, Q., Lv, Y., Wang, Q., Yang, G., Zhou, Z., & Liu, Z. (2015). Transbody against hepatitis B virus core protein inhibits hepatitis B virus replication in vitro. International immunopharmacology, 25(2), 363–369. 

近五年参与发表的文章：

1.     Kaining Zhang, Shanshan Li, Yawen Wang, Zhihao Wang, Nancy Mulvenna, Hang Yang, Peipei Zhang, Huan Chen, Yan Li, Hongliang Wang , Yongxiang Gao, Sivaramesh Wigneshweraraj, Steve Matthews, Kaiming Zhang, Bing Liu. (2022).Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor. Cell Rep. 5;40(1):111026.

2.     Wang, Z., Zhao, S., Li, Y., Zhang, K., Mo, F., Zhang, J., Hou, Y., He, L., Liu, Z., Wang, Y., Xu, Y., Wang, H., Buck, M., Matthews, S. J., & Liu, B. (2021). RssB-mediated σ^S Activation is Regulated by a Two-Tier Mechanism via Phosphorylation and Adaptor Protein - IraD. Journal of molecular biology, 433(3), 166757.

3.     Ren, Y., Liu, W., Zhang, L., Zhang, J., Bi, J., Wang, T., Wang, M., Du, Z., Wang, Y., Zhang, L., Wu, Z., Lv, Y., Meng, L., & Wu, R. (2021). Milk fat globule EGF factor 8 restores mitochondrial function via integrin-medicated activation of the FAK-STAT3 signaling pathway in acute pancreatitis. Clinical and translational medicine, 11(2), e295.

4.     Zhang, D., Guo, R., Lei, L., Liu, H., Wang, Y., Wang, Y., Qian, H., Dai, T., Zhang, T., Lai, Y., Wang, J., Liu, Z., Chen, T., He, A., O'Dwyer, M., & Hu, J. (2021). Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes. Journal of leukocyte biology, 109(1), 13–22.

5.     Li, Y., Li, G., Wang, Z., Chen, W., Wang, H., Wang, Y., & Liu, B. (2021). Resonance assignments of the cytoplasmic domain of ECF sigma factor W pathway protein YsdB from Bacillus subtilis. Biomolecular NMR assignments, 15(1), 103–106.

6.     Yang, Y., Ke, Z., Wang, Z., Li, Y., Li, Y., Wang, Y., & Liu, B. (2020). ¹H, ¹³C and ¹⁵ N NMR assignments of solubility tag protein Msyb of Escherichia coli. Biomolecular NMR assignments, 14(2), 251–254.

7.     Wei, S., Bi, J., Yang, L., Zhang, J., Wan, Y., Chen, X., Wang, Y., Wu, Z., Lv, Y., & Wu, R. (2020). Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice. Clinical and translational medicine, 10(5), e173.

8.     Bi, J., Zhang, J., Ren, Y., Du, Z., Zhang, Y., Liu, C., Wang, Y., Zhang, L., Shi, Z., Wu, Z., Lv, Y., & Wu, R. (2020). Exercise hormone irisin mitigates endothelial barrier dysfunction and microvascular leakage-related diseases. JCI insight, 5(13), e136277.

9.     Wang, Z., Liang, Y., Liu, H., Wang, Y., Wang, H., & Liu, B. (2020). Resonance assignments of bacteriophage SPO1 Gp49 protein. Biomolecular NMR assignments, 14(1), 111–114.

10.  Zhang, J., Ke, M., Ren, Y., Bi, J., Du, Z., Zhang, M., Wang, Y., Zhang, L., Wu, Z., Lv, Y., & Wu, R. (2019). Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma. Disease markers, 2019, 9850191.

11.  Wang, Z., Zhao, S., Jiang, S., Wang, Y., Buck, M., Matthews, S., & Liu, B. (2019). Resonance assignments of N-terminal receiver domain of sigma factor S regulator RssB from Escherichia coli. Biomolecular NMR assignments, 13(2), 333–337.

12.  Zhang, P., Wang, Z., Zhao, S., Wang, Y., Matthews, S., & Liu, B. (2019). ¹H, ¹³C and ¹⁵N NMR assignments of Bacillus subtilis bacteriophage SPO1 protein Gp46. Biomolecular NMR assignments, 13(1), 245–247.

13.  Liu, B., Wang, Z., Lan, L., Yang, Q., Zhang, P., Shi, L., Lang, Y., Tabib-Salazar, A., Wigneshweraraj, S., Zhang, J., Wang, Y., Tang, Y., Matthews, S., & Zhang, X. (2018). A Rapid Colorimetric Method to Visualize Protein Interactions. Chemistry (Weinheim an der Bergstrasse, Germany), 24(26), 6727–6731.

14.  Wang, W., Li, Y., Wang, Y., Ren, S., Li, Y., & Wang, B. (2018). Polyactin A is a novel and potent immunological adjuvant for peptide-based cancer vaccine. International immunopharmacology, 54, 95–102.

15.  Wang, X., Li, Y., Chen, W., Wang, Y., Hui, L., Liu, J., Li, N., Zhang, L., Zou, Y., & Wang, F. (2017). Nrf-2/Gst-α mediated imatinib resistance through rapid 4-HNE clearance. Experimental cell research, 353(2), 72–78.

16.  Sun, Y., Mo, L., Feng, X., Yang, D., Tan, T., Zeng, L., Hui, L., Wang, Y., Liu, C., & He, L. (2017). Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population. Pharmacogenomics, 18(3), 255–264.

奖励

 陕西省人民政府，陕西省科学技术进步奖，三等奖，2012年．

《肾综合征出血热β整合素相关发病机理和疾病严重程度临床评价研究》

专利

1. 专利名称：一种鸭乙型肝炎病毒的荧光定量PCR检测方法及试剂．发明专利号：201310046253.8（第一发明人）

2. 专利名称：一种靶向病毒核心蛋白的穿膜抗体及其制备方法．专利受理号：201310418409.0（第一发明人）

3. 专利名称：血栓诊断和或治疗用含气干粉活性剂及其制备工艺．发明专利号：2005100442767.1（第五发明人）

学会任职：

1. 中国医药生物技术协会组织生物样本库分会常务委员、数据规范和应用学组副组长

2. 中国研究型医院学会临床数据与样本资源库专业委员会副主任委员

3. 中国中西医结合学会检验医学专业委员会委员

4. 中国医疗保健国际交流促进会临床微生物与感染分会委员

5. 中国医学装备协会基因检测分会委员

6. 中国优生科学协会妇儿临床分会副主任委员

7. 陕西省医师协会检验医师分会常务委员

8. 陕西省中西医结合学会检验医学专业委员会常务委员

9.陕西省抗癌协会肿瘤精准诊疗专业委员会副主委员