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韩省力  
研究领域(方向)

1. 细胞膜色谱分析

2. 中药物质基础分析

3. 医药智能分析装备研发及示范性应用

个人及工作简历

1.2005.09-2009.07,西安交通大学,药学,理学学士

2.2009.09-2014.09,西安交通大学,药物分析学,医学博士

3.2014.10~2018.03,西安交通大学,药学院,新讲师

4.2016.12~2017.12,美国威斯康星大学,药学院,访问学者

5.2017.06~2018.03,西安交通大学,药学院,新讲师/硕士生导师

6.2018.03~2020.05,西安交通大学,药学院,副教授/硕士生导师

7.2020.06~2023.12,西安交通大学,药学院,副教授/博士生导师

8.2024.01~现今,西安交通大学,药学院,教授/博士生导师

科研项目

[1]国家自然科学基金面上项目(81973278),基于肥大细胞的中药类过敏组分筛选及致敏效应评价方法研究,2020.01-2023.12,主持。

[2]中国博士后科学基金特别资助项目(2019T120923),基于LAD2细胞释放模型的药物类过敏反应评价方法研究,2019.07-2022.06,主持。

[3]陕西省重点研发计划一般项目-社发领域(2020SF-309),多靶点细胞膜色谱模型的建立及在陕西“七药”抗肿瘤活性组分筛选中的应用,2020.01-2021.12,8万元,主持。

[4]中国博士后科学基金面上I等(2018M641003),细胞膜色谱用于多靶点抗肿瘤活性组分的筛选研究,2018.09-2020.02,主持。

[5]西安交通大学医学部国家级人才后备人选攀登人才支持计划(西交医人[2019]19号),2019.07-2022.07,主持。

[6]国家自然科学基金青年项目(81503032),基于二维液相色谱的中药注射液质量控制方法研究应用,2016.01-2018.12,主持。

[7]陕西省自然科学基金面上项目(2017JM8050),Dual-Mixed CMC的建立及在复杂体系中目标组分识别的应用,2017.01-2018.12,主持。

[8]中国博士后科学基金特别资助项目(2016T90930),多受体细胞膜色谱模型的建立及在目标组分识别中的应用,2016.07-2019.07,主持。

[9]中国博士后科学基金面上I等(2015M570844),基于细胞膜色谱技术的丹红注射液质量控制方法研究,2015.07-2016.12,主持。

[10]陕西省博士后科学基金特别资助项目,细胞膜色谱筛选延胡索抗肿瘤作用活性成分及药理验证,2016.07-2019.07,主持。

学术及科研成果、专利、论文

[1]教育部高等学校科学技术发明一等奖,中药提质增效分析装备工程化及示范应用. 韩省力,第三完成人,证书号:2022-300-R03

[2]陕西省科学技术奖一等奖,基于CMC技术的类过敏物筛选体系的构建及应用. 韩省力,第四完成人,证书号:2017-1-32-R4.

[3]陕西省科学技术奖二等奖,二维联用色谱技术在药物筛选和乳制品分析中的应用. 韩省力,第三完成人,证书号:2016-2-084-R3.

[4]韩省力,张涛,贺浪冲,付佳,吕艳妮,林园园. 一种以聚乙烯醇微球为载体的细胞膜色谱柱及其制备方法. ZL201910385950.3, 2021年01月19日。

[5]贺浪冲,韩省力,张涛,丁园园,刘瑞,王楠. 一种抗MrgprX2抗体的优势抗原表位多肽及其应用. ZL201910469478.1,2021年4月20日。

[6]贺浪冲,韩省力,付佳,张涛,贺怀贞,林园园,吕艳妮. 一种基于固定化SNAP-tag融合蛋白的细胞膜色谱柱及其制备方法. ZL201910385025.0, 2020年10月27日。

[7]贺浪冲,韩省力,张涛,吕艳妮,马维娜. 一种双靶标细胞膜色谱柱及其制备方法和应用. ZL201710100595.1, 2018年10月30日。

[8]Yifan Ding, Na Guo, Yuhan Jiang, Sihan Liu, Tongpei Zhou, Haoyun Bai, Yanni Lv, Shengli Han*, Langchong He*. Establishment of cluster of differentiation 20 immobilized cell membrane chromatography system for the screening of active antitumor components in traditional Chinese medicine. Journal of Chromatography A, 2024, Accepted.

[9]Jingting Feng, Yuhan Jiang, Sihan Liu, Linge Deng, Yanni Lv, Nanzheng Chen, Shengli Han*. KIT‑SNAP‑tag/cell membrane chromatography model coupled with liquid chromatography–mass spectrometry for anti‑GIST compound screening from Evodia rutaecarpa. Analytical and Bioanalytical Chemistry, 2024, 416: 1457-1468.

[10]Qianqian Jia, Yanni Lv, Chenyang Miao, Jingting Feng, Yifan Ding, Tongpei Zhou, Shengli Han*, Langchong He*. A new MrgprX2 cell membrane chromatography analysis model based on HALO-tag technology and its applications. Talanta, 2024, 268: 125317.

[11]Yanni Lv, Saisai Wang, Yamin Wang, Xin Zhang, Qianqian Jia, Shengli Han*, Langchong He. Construction and Application of Covalently Bonded CD147 Cell Membrane Chromatography Model Based on Polystyrene Microspheres. Analytical and Bioanalytical Chemistry, 2023, 415: 1371-1383.

[12]Hong Wang, Qianqian Jia, Jingting Feng, Chenyang Miao, Yifan Ding, Sihan Liu, Yanni Lv, Jing Huang, Shengli Han*. Establishment of ACE2 and CD147 dual target cell membrane chromatography based on SNAP-tag technology for screening anti SARS-CoV-2 active components. Journal of Chromatography A, 2023, 1693: 463903.

[13]Jia Fu, Qianqian Jia, Peida Liang, Saisai Wang, Huaxin Zhou, Liyang Zhang, Hong Wang, Chunlei Gao, Yanni Lv, Shengli Han*, Langchong He*. Enhanced stability designs of cell membrane chromatography for screening drug leads. Journal of Separation Science, 2022, 45(14): 2498-2507.

[14]Jia Fu, Yanni Lv, Qianqian Jia, Cheng Wang, Saisai Wang, Peida Liang, Shengli Han*, Langchong He*. Purification and determination of antibody drugs in bio-samples by EGFR/cell membrane chromatography method. Journal of Pharmaceutical and Biomedical Analysis, 2022, 217: 114808.

[15]Huaxin Zhou, Jia Fu, Qianqian Jia, Saisai Wang, Peida Liang, Yamin Wang, Yanni Lv, Shengli Han*. Magnetic nanoparticles covalently immobilizing epidermal growth factor receptor by SNAP-Tag protein as a platform for drug discovery. Talanta, 2022, 240: e123204.

[16]Qianqian Jia, Jia Fu, Peida Liang, Saisai Wang, Huaxin Zhou, Liyang Zhang, Yanni Lv, Shengli Han*. Investigating of interactions between chiral isomers of chloroquine and hydroxychloroquine and ACE2 by a cell membrane chromatography method. Journal of Separation Science, 2021, 45(2): 456-467.

[17]Jia Fu, Qianqian Jia, Peida Liang, Saisai Wang, Huaxin Zhou, Liyang Zhang, Chunlei Gao, Hong Wang, Yanni Lv, Shengli Han*. Targeting and Covalently Immobilizing the EGFR through SNAP-tag Technology for Screening Drug Leads, Analytical Chemistry, 2021, 93, 11719-11728.

[18]Yanni Lv, Saisai Wang, Peida Liang, Yamin Wang, Xin Zhang, Qianqian Jia, Jia Fu, Shengli Han*, Langchong He. Screening and evaluation of anti-SARS-CoV-2 components from Ephedra silica by ACE2/CMC-HPLC-IT-TOF-MS approach. Analytical and Bioanalytical Chemistry, 2021, 413: 2995-3004.

[19]Wei Sun, Saisai Wang, Peida Liang, Huaxin Zhou, Liyang Zhang, Qianqian Jia, Jia Fu, Yanni Lv, Shengli Han*. Pseudo-allergic compounds screened from Shengmai Injection by using high-expression Mas-related G protein-coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry. Journal of Separation Science, 2021, 44: 1421-1429.

[20]Liyang Zhang, Xinyao Yi, Saisai Wang, Peida Liang, Huaxin Zhou, Jia Fu, Qianqian Jia, Jiapan Gao, Yanni Lv, Shengli Han*. Construction of graphene quantum dots-decorated EGFR cell membrane chromatography for screening active components from Peucedanum praeruptorum Dunn. Analytical and Bioanalytical Chemistry, 2021, 413: 1917-1927.

[21]Jia Fu, Qianqian Jia, Huaxin Zhou, Liyang Zhang, Saisai Wang, Peida Liang, Yanni Lv, Shengli Han*. Cell membrane chromatography for the analysis of the interaction between chloroquine and hydroxychloroquine with ACE2 receptors. Journal of Chromatography B, 2021, 1162: e122469.

[22]Yuanyuan Lin, Qianqian Jia, Wei Sun, Jia Fu, Yanni Lv, Yajing Hou, Cheng Wang, Shengli Han*. Multi targeted cell membrane chromatography: A comprehensive method for screening the anaphylactoid components from complex samples. Talanta, 2020, 209: e120539.

[23]Yanni Lv, Jia Fu, Qianqian Jia, Hengtao Dong, Shengli Han*, Lingjun Li*, Langchong He. A liquid chromatography tandem mass spectrometry based label-free quantification method for assessment of allergen-induced anaphylactoid reactions. Journal of the American Society for Mass Spectrometry, 2020, 31: 856-863.

[24]Yuanyuan Lin, Jing Xu, Qianqian Jia, Wei Sun, Jia Fu, Yanni Lv, Shengli Han*. Cell membrane chromatography coupled online with HPLC-ESI-IT-TOF-MS method to screen anti-anaphylactoid components from Magnolia biondii Pamp.targeting on MrgprX2 receptor. Journal of Separation Science, 2020, 43: 2571-2578.

[25]Qianqian Jia, Wei Sun, Liyang Zhang, Jia Fu, Yanni Lv, Yuanyuan Lin, Shengli Han*. Screening the anti‐allergic components in Saposhnikoviae Radix using high‐expression Mas‐related G protein‐coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry. Journal of Separation Science, 2019, 42: 2351-2359

[26]Yanni Lv, Xianpeng Shi, Jia Fu, Qianqian Jia, Yuanyuan Lin, Hongying Wang, Xin Yang, Shengli Han*. Screening potential antagonists of epidermal growth factor receptor from Marsdenia tenacissima via cell membrane chromatography model assisted by HPLC–ESI–IT–TOF–MS. Biomedical Chromatography, 2019, 33: e4569.

[27]Jia Fu, Yanni Lv, Qianqian Jia, Yuanyuan Lin, Shengli Han*. Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors. Talanta, 2019, 192: 248-254.

联系方式
电子邮箱:slhan2008@mail.xjtu.edu.cn
联系电话:029-82655451
联系地址:陕西省西安市雁塔西路76号
更新日期:2024-03-26