温玉荣 |
1.感染与免疫及病原宿主相互作用的分子机制研究
2.一体化结构生物学方案进行抗感染和抗肿瘤的相关转化医学研究
温玉荣,西安交通大学医学部,研究员,博士生导师。2014年获得比利时根特大学博士学位,2018-2019加拿大阿尔伯塔大学高级访问学者。近五年主持国家及各类省部级项目15项,其中国家自然科学基金4项,教育部留学回国基金,陕西省自然科学基金等,总经费逾500万元。担任国家自然科学基金,中国博士后基金,陕西省自然科学基金评审专家。
从事使用一体化结构生物学方案进行抗感染和抗肿瘤的分子机制以及相关转化医学研究,在病原微生物对环境的响应调控以及病原宿主相互作用分子机制研究取得多个重要进展。在ACS Central Science,Nature Communications,Nucleic Acids Research等国际一流期刊发表SCI学术论文30余篇,以第一和通讯作者发表影响因子大于10的论文4篇,单篇第一作者论文引用超160余次,获批国家发明专利2项。研究工作多次被国际国内媒体报道,并且多次受邀在国际会议上做口头报告,获得加拿大Alberta Parkinson Society Fellowship,中国生物化学与分子生物学会青年科学论坛奖等奖项。1.国家自然科学基金面上项目鲍曼不动杆菌转录调控元件毒力因子的作用机制研究 82072237 2021.1-2024.12
2.国家自然科学基金面上项目 多重耐药鲍曼不动杆菌RND家族药物外排泵的结构与调控机制研究 31870132 2019.1-2022.12
3.国家自然科学基金应急管理项目 二元调控系统介导新生儿严重细菌感染毒素分泌和多重耐药的分子机制研究 81741088 2018.1-2018.12
4.国家自然科学基金青年项目 分子伴侣CsgE/CsgF调控Curli分泌和组装的结构和功能研究 31500051 2016.1-2018.12
5.陕西省自然科学基金 金黄色葡萄球菌ArlRS二元调控系统的分子机制研究 2020JQ-084 2020.1-2021.121.Yufeng Zhao, Yi Shen, Yurong Wen*, and R.E. Campbell*. (2020) “High performance intensiometric direct- and inverse-response genetically encoded biosensors for citrate”. ACS Central Science. 6. 1441-1450. (IF: 12.685)
2.Yibo Ren, Zhenlin Ouyang, Zhanwu Hou, Yuwei Yan, Zhe Zhi, Mengjin Shi, Mengtao Du, Huadong Liu, Yurong Wen*, Yongping Shao*. (2020) CIC is a mediator of the ERK1/2-DUSP6 negative feedback loop. iScience. 23(11): 101635 (Cell 子刊)
3.Zhenlin Ouyang#, Fang Zheng#, Yingmei Pei, Jinhong Zhou, Keqing Wen, Miao Han, Peter M. Hwang, M. Joanne Lemieux, Yurong Wen*. (2019) Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR. Nucleic Acids Research. 47(21):11418-11429.(IF: 11.56)
4.Zhenlin Ouyang, Jan Felix, Jinhong Zhou, Yingmei Pei, Peter M Hwang, M Joanne Lemieux, Irina Gutsche, Fang Zheng, Yurong Wen*. (2020) Trimeric structure of Kupffer cell C-type lectin receptor Clec4f. FEBS Letters. 594(1):189-198(IF: 3.2)
5.Yurong Wen#,*, Zhenlin Ouyang#, Yue Yu, Xiaorong Zhou, Yingmei Pei, Bart Devreese, Paul G Higgins, Fang Zheng* (2017). Mechanistic insight into how multidrug resistance Acinetobacter baumannii response regulator AdeR recognize its promoter DNA. Nucleic Acids Research.45(16): 9773-9787. (IF: 11.56)
6.Yurong Wen, Ester Behiels, Jan Felix, Jonathan Elegheert, Bjorn Vergauwen, Bart Devreese*, Savvas Savvides*. (2014). The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Research. 42(15): 10134-47. (IF: 11.56)
7.Fang Zheng, Siyu Luo, Zhenlin Ouyang, Jinhong Zhou, Huanye Mo, Steve Schoonooghe, Serge Muyldermans, Patrick De Baetselier, Geert Raes*, and Yurong Wen*. (2019) NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis. International Journal of Molecular Sciences. 20(13), 3347. (IF: 4.6)
8.Yurong Wen#, *, Zhenlin Ouyang#, Bart Devreese, Wangxiao He, Yongping Shao, Wuyuan Lu, Fang Zheng* (2017). Crystal structure of master biofilm regulator CsgD regulatory domain reveals an atypical receiver domain. Protein Science. 26: 2073-2082. (IF: 3.8)
9.Yurong Wen*, Zhenlin Ouyang*, Steve Schoonooghe, Siyu Luo, Patrick De Baetselier, Wuyuan Lu, Serge Muyldermans, Geert Raes, Fang Zheng. (2017). Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity. Immunobiology. 222(6): 807-813. (IF: 3.1)
10.Yurong Wen, Frank Sobott, Bart Devreese. (2016). ATP and autophosphorylation driven conformational changes of HipA kinase revealed by ion mobility and crosslinking mass spectrometry. Analytical and Bioanalytical Chemistry. 408:5925–5933. (IF: 3.4)