1. 神经系统退行性疾病的发病机制及防治

2. 神经胶质细胞与阿尔茨海默病

2000年本科毕业于西安交通大学临床医学专业，同年留校任教，历任形态中心、人体解剖与组织胚胎学系助教、讲师、副教授、教授。2004年获西安交通大学病理学与病理生理学专业硕士学位，2016年获西安交通大学人体解剖与组织胚胎学专业博士学位。2016年到2017年作为访问学者在美国哈佛大学医学院从事科研工作一年半。

主讲中英文解剖学课程10门，主编、参编教材16部，主持和参与教改项目15项，发表教学论文16篇，获西安交通大学第十九届本科教学成果二等奖。培养的研究生获陕西省第六届研究生创新成果优秀奖、西安交通大学“优秀留学生标兵”、国家奖学金、西安交通大学优秀硕士学位论文等奖项。指导的本科生获全国大学生基础医学创新研究“二等奖”和“铜奖”各1项（国家级）、获陕西省“挑战杯”大学生课外学术科技作品竞赛“二等奖”、西安交通大学本科生优秀毕业设计（论文）奖等。

主持国家自然科学基金、陕西省自然科学基础研究计划项目、中国博士后科学基金特别资助、中国博士后科学基金面上一等资助、陕西省博士后科研项目面上一等资助、中央高校基本科研业务费、西安交通大学医学“基础-临床”融合创新项目、西安市神经免疫疾病创新转化重点实验室开放课题等项目9项。参与国家级和省部级科研项目6项。

科研论文（通讯作者）

1. Zikang Yang, Xiaoqian Peng, Xiao Zhang, Hongsong Guo, Zihao Li, Xiangyuan Wu, Mingtao Zhao, John Bosco Ruganzu, Congxuan Zhai, Shengfeng Ji, Weina Yang*. Tanshinone IIA promotes hippocampal neurogenesis in ApoE−/− mice through cAMP/PKA/CREB/BDNF signaling pathway. Mol. Neurobiol. 2026,63:144.

2. Hongsong Guo, Xiaoqian Peng, Xiao Zhang, John Bosco Ruganzu, Xiangyuan Wu, Mingtao Zhao, Pengbo Yang, Shengfeng Ji, Weina Yang*. Insulin-like growth factor-1 enhances β-amyloid protein clearance in HMC3 microglia via low-density lipoprotein receptor-related protein 1-mediated pathway. Exp. Cell Res. 2026,457:114920.

3. Xiaoqian Peng#, Zikang Yang#, Hongsong Guo, Xiangyuan Wu, John Bosco Ruganzu, Zhongzhong Liu, Songdi Wu*, Weina Yang*. TREM2 alleviates neuroinflammation and improves neurogenesis in ApoE−/− mice by regulating M1/M2 microglial polarization. Mol. Neurobiol. 2026,63:105.

4. Mengke Wang, Baochen Zhang, Renhao Guo, Haiqin Wang, Di Wu, Xiaoqian Peng, Hongsong Guo, Jiawei Duan, Weina Yang*, Pengyu Ren*, Siyuan Zhang*. Restoration of autophagy-lysosomal function via transcranial focused ultrasound stimulation ameliorates β-amyloid pathology and cognitive deficits in an Alzheimer’s disease model. Ultrasonics. 2026,165:108075.

5. Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Xiangyuan Wu, John Bosco Ruganzu, Songdi Wu, Mingtao Zhao, Lei Li, Yang Yang, Shengfeng Ji, Weina Yang *, Pengyu Ren*. TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice. Exp Neurol. 2025,388:115205.

6. Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yang *. TREM2 inhibits tau hyperphosphorylation and neuronal apoptosis via the PI3K/Akt/GSK-3β signaling pathway in vivo and in vitro. Mol. Immunol. 2023,60:2470-2485.

7. Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng, Weina Yang *. Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice. Eur. J. Pharmacol. 2022,918:174772.

8. John Bosco Ruganzu, Xiaoqian Peng, Xiangyuan Wu, Quzhao Zheng, Bo Ding, Chengheng Lin, Hongsong Guo, Zikang Yang, Xiao Zhang, Weina Yang *. Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease. Mol. Immunol. 2022,142: 22-36.

9. John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Yingying He, Xiaoqian Peng, Hui Jin, Jinsong Zhou, Ruiyang Ma, Shengfeng Ji, Yanbing Ma, Yihua Qian, Yang Wang, Weina Yang *. TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway. Exp Neurol. 2021,113506.

10. Bo Ding, Chengheng Lin,Qian Liu, Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma, Weina Yang *. Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro. J. Neuroinflamm. 2020,17:302.

11. Yingying He, John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Hui Jin, Xiaoqian Peng, Bo Ding, Chengheng Lin, Shengfeng Ji, Yanbing Ma, Weina Yang *. Silencing of LRP1 exacerbates inflammatory response via TLR4/NF-κB/MAPKs signaling pathways in APP/PS1 transgenic mice. Mol. Neurobiol. 2020,57:3727-3743.

12. Yingying He, John Bosco Ruganzu, Chengheng Lin, Bo Ding, Quzhao Zheng, Xiangyuan Wu, Ruiyang Ma, Qian Liu, Yang Wang, Hui Jin, Yihua Qian, Xiaoqian Peng, Shengfeng Ji, Liangliang Zhang, Weina Yang *, Xiaomei Lei*. Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice. Neurochem. Int. 2020,133: 104610.

13. Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma, Liming Zheng, Weina Yang *. LRP1 knockdown aggravates Aβ1–42-stimulated microglial and astrocytic neuroinflammatory responses by modulating TLR4/NF-κB/MAPKs signaling pathways. Exp. Cell Res. 2020,394:112166.

14. Hui Jin, Xiaoqian Peng, Yingying He, John Bosco Ruganzu, Weina Yang *. Tanshinone IIA suppresses lipopolysaccharide-induced neuroinflammatory responses through NF-κB/MAPKs signaling pathways in human U87 astrocytoma cells. Brain Res. Bull. 2020,164: 136-145.