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王一东 |
器官损伤修复机制及干预策略
1. 心脏再生和重塑机制及干预策略。
2.肝脏再生和纤维化机制及干预策略。
2023-至今 西安交通大学第一附属医院 特聘教授
2018-至今 西安交通大学基础医学院，教授
2016-2018 美国阿尔伯特爱因斯坦医学院，遗传系，研究助理
2012-2016 美国阿尔伯特爱因斯坦医学院，遗传系，博士后
2006-2011 四川大学，细胞生物学，博士
2008-2011 美国阿尔伯特爱因斯坦医学院，遗传学系，访问学者
2002-2006 西南交通大学，生物工程，学士
2025-2028 国家自然科学基金面上项目，主持。
2024-2025 企业横向课题-心肌再生修复XXX，主持
2024-2026 陕西省杰出青年基金项目，主持。
2019-2024 科技部重点专项，子课题负责人。
2020-2023 国家自然科学基金面上项目，主持。
2019-2022 陕西省人社厅重点项目，主持。
2018-2021 陕西省青年人才计划项目，主持。
2018-2024 西安交通大学“青年拔尖人才计划”A类项目, 主持。
2013-2015 美国心脏协会博士后基金, 主持。
2011-2016 美国国立卫生研究院R1项目, 参与。
发表论文情况（*通讯作者；#并列一作）
1. Huahua Liu#, Jinling Dong#, Shuang Liu#, Yuru Luo, Yuan Fang, Hongyu Su, Weihao Xue, Rui Zhou, Wenjun Huang, Baochang Lai, Ying Xiong, Shuangshuang Wang, Lingli Liang, Zhen Wang, Donghong Zhang, Lianpin Wu, Yanmin Zhang, Bin Zhou, John Y-J Shyy*, Zuyi Yuan*, Yidong Wang*. Regulation of heart regeneration by LSD1 through suppressing CEND1.Theranostics. 2025.
2. Shan He#, Yuru Luo#, Wangge Ma#, Xiaoke Wang#, Chengrong Yan, Wenyang Hao, Yuan Fang, Hongyu Su, Baochang Lai, Junhui Liu, Ying Xiong, Ting Bai, Xiaoyong Ren, Enqi Liu, Hua Han, Yue Wu*, Zuyi Yuan*, Yidong Wang*. Endothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis. Journal of Hepatology. 2024.
3. Huahua Liu#, Rui Zhou#, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J Shyy, Bin Zhou, Zuyi Yuan*, Yidong Wang*. Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024.
4. Huahua Liu#, Pengfei Lu#, Shan He, Yuru Luo, Yuan Fang, Sonia Benkaci, Bingruo Wu, Yidong Wang*, Bin Zhou*. β-Catenin regulates endocardial cushion growth by suppressing p21. Life Science Alliance. 2023.
5. Bingruo Wu#, Brian Wu#, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice Morrow, Yidong Wang*, Bin Zhou*. Crk and Crkl are required in the endocardial lineage for heart valve development. Journal of the American Heart Association. 2023.
6. Pengfei Lu#; Yidong Wang#; Yang Liu; Yifeng Wang; Bingruo Wu; Deyou Zheng, Richard P. Harvey; Bin Zhou*; Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signaling. Nature Cell Biology. 2021.
7. Yidong Wang*; Yuan Fang; Pengfei Lu; Bingruo Wu; Bin Zhou*. NOTCH signaling in aortic valve development and calcific aortic valve disease. Frontiers in Cardiovascular Medicine. 2021.
8. Yidong Wang*, Pengfei Lu, Liping Jiang, Bingruo Wu, Bin Zhou*. Control of sinus venous valve and sinoatrial node development by endocardial NOTCH1. Cardiovascular Research. 2020.
9. Yidong Wang*,#, Pengfei Lu#, Bingruo Wu, Bernice Morrow, Bin Zhou*. NOTCH maintains developmental cardiac gene network through WNT5A. Journal of Molecular Cellular Cardiology. 2018.
10. Yidong Wang*, Pengfei Lu, Bingruo Wu, Dario F. Riascos-Bernal, Nicholas E.S Sibinga, Tomas Valenta, Konrad Basler, Bin Zhou*. Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation. Journal of Molecular Cellular Cardiology. 2018.
11. Yidong Wang, Bingruo Wu, Pengfei Lu, Donghong Zhang, Feng Xiao, Shweta Vashney, Zhenwu Zhuang, Nicholas E.S Sibinga, Nikolaos G. Frangogiannis, Kitsis Richard, David Sharp, Pamela Stanley, Bin Zhou*. Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nature Communications. 2017.
12. Yidong Wang, Bingruo Wu, Emily Farrar, Wendy Lui, Pengfei Lu, Donghong Zhang, Christina M. Alfieri, Kai Mao, Ming Chu, Di Yang, Di Xu, Michael Rauchman, Verdon Taylor, Simon Conway, Katherine E. Yutzey, Jonathan T. Butcher, Bin Zhou*. Notch-Tnf signaling is required for development and homeostasis of arterial valves. European Heart Journal. 2017.
13. Bingruo Wu#, Yidong Wang#, Feng Xiao, Jonathan T. Butcher*, Katherine E. Yutzey*, Bin Zhou*. Development mechanisms of aortic valve malformation and disease. Annual Review of Physiology. 2017.
人才称号：陕西省杰青、青年人才，西安交通大学“青年拔尖人才”A类
