1.超声黏弹性成像理论及方法研究，超声黏弹性成像在临床早期疾病诊断中的应用研究

2.组织与细胞黏弹性参数与疾病发生发展关系研究

3. AI影像与医学大数据分析在早期疾病筛查中的应用研究

4.有限元分析与数值计算在生物力学中的应用

1. Ultrasound viscoelastic imaging on major disease diagonosis (Vulnerability evaluation for Carotid plaque by ultrasound viscoelastic imaging, Early sifting of breast cancer by Ultrasound viscoelastic imaging)

2.Fractional derivative based viscoelastic imaging method (by ultrasound and by indentation/nanoindentation or atomic force microscopy in nano scale )

3.Artificial Intelligence in medical data and early screening of diseases.

4. Biomedical mechanics and simulation by FEM

助教(1996.9-1997.7)：西安理工大学材料学院；

讲师(2004.10-2008.7): 西安交通大学生命科学与技术学院；

副教授(2008.8-至今)：西安交通大学生命科学与技术学院。

1.国家自然科学基金面上项目：分数阶黏弹性和流性参量表征颈动脉粥样硬化斑块易损性的超声成像方法和实验研究（批准号No. 61871316，起止时间：2019.1.1-2022.12.31, 经费63万）

2国家自然科学基金青年项目：超分辨超声血管应变估计和弹性成像方法和实验研究（批准号No.60801057，起止时间：2009.1.1-2011.12.31,经费20万）

3 西安交通大学重点研发专项：超声黏弹性参数表征在早期乳腺肿瘤筛查中的应用研究（zdyf2017011，15万，已结题）

4. 西安交通大学国际合作项目：颈动脉血管壁斑块特性的超声弹性成像评估（xjj2008027，4万，已结题）

5.西安交通大学校长基金项目：超声血管超分辨应变与弹性成像理论方法及实验（2012jdhz50，1万，已结题） 

作为项目骨干参与重大国家级科研项目3项

1.万明习国家重大仪器专项课题:超声脑小血管多分辨及动态多参量成像系统（批准号81827801起止时间：2019.01-2023.12 经费 796.72万元）

2. 万明习 国家973项目课题：易损斑块无创、高分辨超声功能与分子定量成像，（批准号2010CB732603，起止时间：2010.01-2014.08，经费396万元）

3. 王素品基于组织内相变微泡振动模型参数反求的微弹性成像11474229起止时间：2015.01-2018.12 经费94万元）

[1]  Hongmei Zhang, Tongqing Lu, Qingzhe Zhang, Yan Zhou, Hongrui Zhu, Joseph Harms, Xiaofeng Yang, Mingxi Wan*, Michael F. Insana*, Solutions to ramp-hold dynamic oscillation indentation tests for assessing the viscoelasticity of hydrogel by Kelvin-Voigt fractional derivative modeling, Mechanics of Materials, 2020, 148 (103431):1-15. DOI: 10.1016/j.mechmat.2020.103431

[2]  HONGMEI ZHANG, LEI XU, ZHIHUI LIU, SHUKUAN LU, JICHAO YIN, SIBO TIAN, XIAOFENG YANG, MINGXI WAN*. Statistical and Texture Descriptors of Symptomatic Plantar Fasciitis Using Ultrasound Shear Wave Elastography. IEEE Access. 2020:8,120146-120159. DOI: 1-1. 10.1109/ACCESS.2020.3005829.

[3]  Hongmei Zhang , Ying Guo , Yan Zhou, Hongrui Zhu, Manman Song, Kai Wang, Meili Gao, Litao Ruan, Mingxi Wan, Michael F. Insana*, Fluidity and elasticity form a concise set of viscoelastic biomarkers for breast cancer diagnosis based on Kelvin–Voigt fractional derivative modeling, Biomechanics and Modeling in Mechanobiology , Biomechanics and Modeling in Mechanobiology, 2020,19:19:2163–2177 (DOI:10.1007/s10237-020-01330-7)

[4]  HONGMEI ZHANG, MANMAN SONG,LITAO RUAN,FURONG ZHANG, AIFENG ZHANG, ANDREW M. SIEDLECKI, MINGXI WAN. Von Mises Strain as a Risk Marker for Vulnerability of Carotid Plaque: Preliminary Clinical Evaluation of Cerebral Infarction. Ultrasound Med Biol 2019, 45:1221-1233. DOI: 10.1016/j.ultrasmedbio.2019.01.007

[5]  Hongmei Zhang, Qingzhe Zhang，Litao Ruan, Mingxi Wan, Michael F.Insana. Modeling Ramp-hold Indentation Measurements based on Kelvin-Voigt Fractional Derivative Model. Measurement Science and Technology. 2018, 29(3), 1-16. DOI: 10.1088/1361-6501/aa9daf.

[6]  Hongmei Zhang, Yue Wang, Mostafa Fatemi , Michael Insana. Assessing composition and structure of soft biphasic media from Kelvin-Voigt fractional derivative model parameters", Measurement Science and Technology. 2017, 28 (2017) 035703 (12pp) doi:10.1088/1361-6501/aa5531.

[7]  HongMei Zhang^1,2, Yue Wang², Michael F. Insana², Ramp-hold relaxation solutions for the KVFD model applied to soft viscoelastic media. Measurement Science and Technology, 27 (2016) :1-11.

[8]  Zhang HM, Song MM, Yang M, Ruan LT, Wan MX. Fast Von Mises Strain Imaging on Ultrasound Carotid Vessel Wall by Flow Driven Diffusion Method, AUSTRALAS PHYS ENG S 2018: 1-18.

[9]  HongMeiZhang, Yue Wang, LiTao Ruan, Junbo Duan, MingXi Wan ,Non-invasive Von Mises Strain imaging for Longitudinal Artery Wall. Journal of Medical Imaging and Health Informatics, 2016,6(4):906-915.

[10]   HongMei Zhang, HuiE Zhang, JunFeng Wu, et al. "Detection of thin structure defects in radiographic images using an improved Gabor filter." Insight - Non-Destructive Testing and Condition Monitoring 59.10(2017):531-536.

[11]   Zhang Hongmei, Wan Mingxi, Bian Zhengzhong. Complementary tensor-driven image coherence diffusion for oriented structure enhancement. EURASIP Journal on Advances in Signal Processing 2011, 2011:70http://asp.eurasipjournals.com/content/2011/1/70.

[12]   HongMei Zhang, MingXi Wan, JinJin Wan,XuLei Qin. Super-Resolution Reconstruction of Deformable Tissue from Temporal Sequence of Ultrasound Images, 2010 International conference on artificial Intelligence and Computational Intelligence. Vol. 1, pp.337-342.

[13]   Hongmei Zhang，Mingxi Wan, Bo Shen, Xiaodong Wang, Mingzhu Lu. Volume estimation in a sequence of freehand ultrasound images. Measurement Science and Technology. 2006, 17 (11): 2927-2937.

[14]   Zhang Hongmei，Wan Mingxi. Improved Mumford-Shah Functional for Coupled Edge-Preserving Regularization and Image Segmentation. EURASIP Journal on Applied Signal Processing. 2006 Art. No. 37129 : 1-9

[15]   Zhang Hongmei，Bian Zhengzhong, Guo Youmin, Ye Min, Miao Yalin. Region information-based ROI extraction by multi-initial fast marching algorithm.  EURASIP Journal on Applied Signal Processing，2004,11:1739-1749.

[16]   Zhang Hongmei, Bian Zhengzhong, Yuan Zejian, Ye Min, Ji Feng. A novel multiresolution fuzzy segmentation method on MR image. Journal of Computer Science and Technology, 2003, 18(5): 659-666.

[17]   Zhang Hong-mei，Bian Zheng-zhong ,Guo You-min, Ye Min. Efficient approach to extraction of region of interest, Journal of Software, 2005, 16(1): 77-88.

[18]   Zhang Hongmei, Bian Zhengzhong, Jiang Dazong, Yuan Zejian, Ye Min. Level set method for pulmonary vessels extraction. IEEE International Conference on Image Processing, Barcelona, Spain, 14-17 September 2003, 2:1105-1108.

[19]   Hongmei Zhang, Zhengzhong Bian, Youmin Guo, Baowei Fei, Min Ye. An efficient multiscale approach to level set evolution. The 25th Silver Anniversary International conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 17-21 Sept. 2003, 694-697.

[20]   Zhang Hong-mei, Yuan Ze-jian, Cai Zhong-min, Bian Zheng-zhong. Segmentation of MRI Using Hierarchical Markov Random Field. Journal of Software, 2002, 13(9): 1779-1786.

[21]   Zhang Hong-mei, Bian Zheng-zhong, Guo You-min, Yuan Ze-jian. An Efficient Approach to Pulmonary Vessels Extraction Based on Curve Evolution. Chinese Journal of Biomedical Engineering (English edition), 2004, 13(1): 39-46.

[22]   Hongmei Zhang, Yalin Miao, Youmin Guo, Jiang Yang, Zhengzhong Bian, Vascular enhancement by anisotropic diffusion-reaction PDE. Microellectronics & Computer, 2004,21(3):25-27.(In Chinese)

[23]   Hongmei Zhang, Donglang Chai, Zhengzhong Bian, a fast subdivision method for grid of composite material. Journal of Applied Mechanics, 2002,19(4):147-149. (In Chinese)

(Chinese National Invention patent)

Zhang Hongmei, Ruan Litao, Zhang qingzhe, Guo Youmin, Wan Mingxi, Shan Baowen. A novel and high accuracy noninvasive elastic imaging of vascular wall. Authorized, ZL 2016012710027191.

Zhang Hongmei, Wang Kai, Liu Zhihui, Zhang Kehao, Zhou Yan, Yang Fan, Wang Jiong, Wan Mingxi. Machine learning optimization method of fractional order KVFD parameters for Viscoelastic characterization of soft matter, CN 202010598527.4 (publicizing)

Book  Chapter (In Chinese)

[1]      Hongmei Zhang, Chapter  7  Elasticity reconstruction of Vascular (Mingxi Wan et al, Computational Ultrasonic imaging), 2019-01, 978-7-03-059103-6 Chinese Science Press.

[2]      Hongmei Zhang, Chapter  8  Fractional derivative model based viscoelastic measurement of biological tissue (Mingxi Wan et al, Computational Ultrasonic imaging ) 2010-05,978-7-03-027204-1 Chinese Science Press

[3]       Hongmei Zhang, Chapter 10 Ultrasound medical image processing (Mingxi Wan et al, Biomedical Ultrasonics),  2010-05,978-7-03-027204-1, Chinese Science Press.

 (Software Copyright)

[1]       Hongmei Zhang ,Litao Ruan, Zhengzhong Bian, Youmin Guo, Mingxi Wan, Variational and d PDE base evolution methods  for image analysis.  (corpyright No. 2014SR080747)

[2]       Hongmei Zhang , Mingxi Wan, Litao Ruan, Volume measurement from free hand Ultrasound images (copyright 2014SR080401)

(Publication as co-corresponding author )

[1]       Yan Song, Ying Dang, Jichang Wang, Hui Cai, Jun Feng, Hongmei Zhang*, Litao Ruan. Carotid intraplaque neovascularization predicts Ischemic Stroke Recurrence in Patients with Carotid Atherosclerosis. Gerontology. 2020. (In Press)

 (Selected Publications as co-author)

[1]       Hongrui Zhu, Dui Qin, Youshen Wu,  Bowen Jing,  Jiajun Liu,  David Hazlewood,  Hongmei Zhang,  Yi Feng,  Xinmai Yang, Mingxi Wan,* , and Daocheng Wu*  Laser-Activated Bioprobes with High Photothermal Conversion Efficiency for Sensitive Photoacoustic/Ultrasound Imaging and Photothermal Sensing. ACS Appl. Mater. Inter 2018, 10:29251-29259.

[2]       Zhu, H., Gan, Z., Li, D., Qin, J., Zhang, H., Wan, M., & Wu, D. (2019). Sensitive detection of dopamine with ultrasound cavitation-enhanced fluorescence method. Microchemical Journal, 150, 104199.

[3]       Jinjin Wan, Fangli He, Yongfeng Zhao, Hongmei Zhang, Xiaodong Zhou, Mingxi Wan. Non-invasive Vascular Radial/Circumferential Strain Imaging and Wall Shear Rate Estimation Using Video Images of Diagnostic Ultrasound. Ultrasound in Medicine & Biology, 2014,40(3), 622-636.