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成瀛  
研究领域(方向)

1. 中枢神经系统和外周组织对能量稳态调控的研究

2. 线粒体与复杂代谢疾病的研究

3. 造血干细胞和血液肿瘤的研究

个人及工作简历

2000-2004  西安交通大学生命科学与技术学院,学士

2004-2010  中国科学院上海营养科学研究所,博士

2011-2016  美国宾夕法尼亚大学医学院、费城儿童医院,博士后

2016-2017  美国费城儿童医院,Research Associate

2017-至今  西安交通大学生命科学与技术学院,副教授

科研项目
学术及科研成果、专利、论文

1. Cheng Y, Chikwava K, Wu C, Zhang H, Bhagat A, Pei D, Choi JK, and Tong W. LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. Journal of clinical investigation. 2016; 126(4):1267-81.

2. Cheng Y, Meng Q, Wang C, Li H, Huang Z, Chen S, Xiao F, and Guo F. Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes. 2010; 59(1):17-25.

3. Cheng Y, Zhang Q, Meng Q, Xia T, Huang Z, Wang C, Liu B, Chen S, Xiao F, Du Y, et al. Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system. Molecular endocrinology. 2011; 25(9):1624-35.

4. Kim E, Cheng Y, Bolton-Gillespie E, Cai X, Ma C, Tarangelo A, Le L, Jambhekar M, Raman P, Hayer K, Wertheim G, Speck N, Tong W and Viatour P. Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by preserving their intracellular cytokine signaling. Journal of experimental medicine. 2017; 214, 1901-1912.

5. Xia T, Cheng Y, Zhang Q, Xiao F, Liu B, Chen S, and Guo F. S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid. Diabetes. 2012; 61(10):2461-71.

6. Zhang Q, Liu B, Cheng Y, Meng Q, Xia T, Jiang L, Chen S, Liu Y, and Guo F. Leptin signaling is required for leucine deprivation-enhanced energy expenditure. The Journal of biological chemistry. 2014; 289(3):1779-87.

7. Jiang J, Balcerek J, Rozenova K, Cheng Y, Bersenev A, Wu C, Song Y, and Tong W. 14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells. The Journal of clinical investigation. 2012; 122(6):2079-91.

8. Wang C, Huang Z, Du Y, Cheng Y, Chen S, and Guo F. ATF4 regulates lipid metabolism and thermogenesis. Cell research. 2010; 20(2):174-84.

9. Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, et al. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes. 2011; 60(3):746-56.

10. Ly K, Jiang J , Donaghy R, Cheng Y, Chandra V, An Wei, Mohapatra B, Goetz B, Pillai V, Han X, Jeschke G, Langdon W, Hexner E, Band H, and Tong W. CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem/progenitor cells and myeloid malignancies, Genes & Development, 2017; 31, 1007-1023.

联系方式
电子邮箱:yingcheng@xjtu.edu.cn
联系电话:
联系地址:西安交通大学生命学院
更新日期:2018-01-08