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GARSTKA MALGORZATA ANNA  
研究领域(方向)
分子免疫学、 MHC I、自身免疫疾病、I型糖尿病
个人及工作简历
1. 2007/09 – 2008/09 荷兰莱顿大学医学中心(Leiden University Medical Center)Emmanuel Wiertz教授团队,博士后研究员
2. 2008/10 – 2009/04 德国不来梅雅各布大学(Jacobs University Bremen) Sebastian Springer教授团队,博士后研究员
3. 2009/05 – 2016/08 荷兰癌症研究中心(The Netherlands Cancer Institute) Jacques Neefjes教授团队, 博士后研究员
4.2016/09 – 现今  西安交通大学第二附属医院 免疫学 教授
科研项目

1.主持2018年国家自然科学基金青年项目《I型主要组织相容性复合体参与1型糖尿病异常自身抗原呈递的机制研究》(81700691)20万,2018/01-2019/12。

2.西安交大“青年拔尖人才支持计划”A类(教授),200万

3.二附院科研启动金,50万,2016/09-2022/08

4.课题“了解自身免疫在一型糖尿病中的作用从而发展出新的诊断方法”获得西安交通大学第二附属医院人才培养专项科研基金,6万,2017/01-2019/12

5.课题“通过纳米微胶囊靶标MHC I蛋白阻滞CD8 T细胞对胰腺的自身免疫性攻击”获得西安交通大学基本科研业务费前沿与综合交叉类项目,12万,2017/01-2019/12

学术及科研成果、专利、论文

1. Song Y., Wu K., Wu W., Duan Z., Gao YF, Zhang L., Chong T., Garstka M.A., Zhou W., and Li K. (2018) Epithelial C5aR1 signalling enhances uropathogenic E coli adhesion to human renal tubular epithelial cells. Frontiers in Immunology 9, 949. IF=6.429.

2. Luimstra J.J*, Garstka M.A.*^, Roex M.C.J., Redeker A., Janssen G.M.C, van Veelen P.A., Arens R., Falkenburg J.H.F, Jacques Neefjes^, Huib Ovaa^ (2018). A rapid and flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cell responses. J Exp Med 215(5): 1493-1504. IF=11.991.

3. Bai F., Zheng W., Dong Y., Wang J., Garstka, M.A., Li R.,, An J., and Ma H. Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis. Oncotarget 9(10):1266-1278.

4. Zhang T., Garstka M., and Li K. (2017). The Controversial C5a Receptor C5aR2: Its Role in Health and Disease. J. Immunol. Res., Article ID 8193932, 16 pages, IF 3.27, cited by 4 (google scholar)

5. Jongsma M.L.M.,*, Berlin I.,* Wijdeven R.H.M., Janssen L., Janssen G.M.C., Garstka M.A., Janssen H., Mensink M., van Veelen P.A, Spaapen R.M., and Neefjes  J. (2016) ER-associated pathway draws the endosomal system’s architecture for controlled cargo transport. Cell, 166:152-66. IF-28.71, cited by 21 (google scholar).

6. Garstka M., Fish A., Celie P.H.N., Joosetn R.P., Janssen G.M.C., Berlin I., Hoppes R., Stadnik M., Janssen L., Ovaa H., van Veelen P.A., Perrakis A., and Neefjes J. (2015) The first step of peptide selection in antigen presentation by MHC class I molecules. Proc Natl Acad Sci U S A., 112:1505-10. Article, IF-9.81, cited by 23 (Google scholar), recommended by Prof. Tim Elliott (University of Southampton, UK) for Faculty of 1000.

7. Garstka M.A^., Neefjes J. (2013). How to target MHC class II into the MIIC compartment. Mol. Immunol., 55: 162-5. IF-3.0, invited review, cited by 7 (Google scholar).

8. Garstka M.A., Fritzsche S., Lenart I., Hein Z., Jankevicius G., Boyle L.H., Elliott T., Trowsdale J., Antoniou A.N., Zacharias M., and Springer S. (2011). Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility. FASEB J., 25: 3989-98. IF-5.71, cited by 39 (Google scholar).

9. Horst D., Favaloro V., Vilardi F., van Leeuwen H.C., Garstka M.A., Hislop A.D., Rabu C., Kremmer E., Rickinson A.B., High S., Dobberstein B., Ressing M.E., and Wiertz E.J. (2011). EBV Protein BNLF2a Exploits Host Tail-Anchored Protein Integration Machinery To Inhibit TAP. J Immunol., 186: 3594-605. IF-5.79, cited by 28 (Google scholar).

10. Howe C.,* Garstka M.,* Al-Balushi M., Ghanem E., Antoniou A.N., Fritzsche S., Jankevicius G., Kontouli N., Schneeweiss C., Williams A., Elliott T., and Springer S. (2009). Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC Class I molecules. EMBO J., 28: 3730-3744. IF-8.99, cited by 70 (Google scholar), recommended by Prof. Joyce Solheim (University of Nebraska Medical Center, USA) for Faculty1000.

11. Palankar R., Skirtach A.G., Kreft O., Bédard M., Garstka M., Gould K., Möhwald H., Sukhorukov G.B., Winterhalter M., and Springer S. (2009). Controlled intracellular release of peptides from microcapsules to follow antigen on MHC class I molecules. Small, 19: 2168-2176. IF-6.17, cited by 105 (Google scholar). This article was featured on the cover of the journal.

12. Schneeweiss C., Garstka M., Smith J., Hütt M.T., Springer S. (2009). The mechanism of action of tapasin in the peptide exchange on MHC class I molecules determined from kinetics simulation studies. Mol Immunol., 46: 2054-2063. Article, IF-2.90 cited by 21 (Google scholar).

13. Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J., Ressing M.E. (2009). Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation. J Immunol., 182: 2313-2324. IF-5.65, cited by 91 (Google scholar)

14. Garstka M.,* Borchert B.,* Al-Balushi M.,* Praveen P.V.K., Kuehl N., Majoul I., Duden R., and Springer S. (2007). Peptide-receptive MHC class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild type lymphocytes. J. Biol., Chem., 282: 30680-30690. IF-5.52, cited by 39 (Google scholar)

15. Sukhorukov G.B., Rogach A.L., Garstka M., Springer S., Parak W.J., Munoz-Javier A., Kreft O., Skirtach A., Susha A.S., Ramaye Y., Palankar R., and Winterhalter M. (2007). Multifunctionalized Polymer Microcapsules: Novel Tools for Biological and Pharmacological Applications. Small, 3: 944-955. Review, IF-6.41, cited by 204 (Google scholar)
* These authors contributed equally to this work
^ corresponding authors

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电子邮箱:m.garstka@xjtu.edu.cn
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更新日期:2018-05-14