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赵新汉  
研究领域(方向)

1.肿瘤靶向基因治疗

2.肿瘤多药耐药

3.肿瘤综合治疗模式探索

4.大数据与云计算

个人及工作简历

1983.9-1988.7西安医科大学临床医学系  本科

1990.9-1993.7西安医科大学肿瘤学专业  硕士

2000.9-2004.6西安交通大学内科学      博士

1988.7-至今  西安交通大学第一附属医院肿瘤内科,任住院医师、主治医师、副主任医师、副教授、主任医师、教授

主攻肿瘤基础与临床研究。现为西安交通大学第一附属医院长安区分院院长,肿瘤内科主任医师、教授,博士生导师,博士后合作导师,西安交通大学“985”三期肿瘤学科带头人,教育部“创新团队发展计划资助”项目组骨干成员。中国医师协会肿瘤放射治疗医师分会第一届委员会委员,中国宋庆龄基金会肿瘤医疗及产学研联盟顾问委员会委员,吴阶平医学会精准医学部副主任委员,陕西省抗癌协会抗癌药物专业委员会主任委员,陕西省药理学会化疗药物专业委员会主任委员,陕西省抗癌协会生物大数据专业委员会主任委员,中国肿瘤防治联盟陕西省乳腺癌专业委员会副主任委员,中国肿瘤防治联盟陕西省鼻咽癌专业委员会副主任委员,陕西省抗癌协会肿瘤个体化诊疗专业委员会副主任委员,陕西省中医药学会肿瘤专业委员会副主任委员,陕西省医学会医学科普分会副主任委员,陕西省抗癌协会常务理事,陕西省药理学会常务理事。

科研项目

1. Notch-YAP正反馈调控乳腺癌细胞自我更新及肺转移的机制研究

2017年国家自然科学基金项目(主持人为本人指导的在职博士生)

(编号:81702908)

2. 基于“热证~代谢”穿越体探讨清热解毒法调控乳腺癌warburg效应的作用机制

2017年国家自然科学基金项目(主持人为本人指导的在职博士生)

(编号:81703899)

3. 髓源性抑制细胞对乳腺癌细胞“干性”获得的生物学和力学特性调控及其分子机制研究

2016年国家自然科学基金项目

(编号:81672626)

4. 基于体外展示技术的乳腺癌干细胞靶分子筛选和进化研究

2012年国家自然科学基金项目

(编号:81272898)

5. 建立于乳腺癌转移时空模型基础上的肿瘤干细胞起源及转归的探索

2010国家自然科学基金项目

(编号:81072181)

6. PRM复合体筛选抗乳腺癌特异性多肽及其分子解析与功能改造

2007国家自然科学基金项目

(编号:30772112)

7. G4PAMAM/VEGFASODN抗乳腺癌血管生成的研究

2005国家自然科学基金项目

(编号:30572140)

8. ASCs介导的CNGRC肽靶向杀伤乳腺癌干细胞微血管龛内皮细胞的分子机制研究

2012国家自然科学基金青年科学基金项目(主持人为本人指导的在职博士生)

  (编号:81201680)

9. Notch信号通路调控EMT转化和肿瘤细胞“干性”获得在乳腺癌侵袭转移中的分子机制研究

2011国家自然科学基金青年科学基金项目(主持人为本人指导的在职博士生)

(编号:81102027)

10. 乳腺癌器官转移倾向性的分子解析——肿瘤干细胞运动时空探索和预期转移灶微环境重塑的关键因素筛选

200     国家自然科学基金青年科学基金项目(主持人为本人指导的在职博士生)

(编号:30801119)

11. 中国常见恶性肿瘤早期诊断复合自身抗体的研究

2009陕西省“13115”科技创新工程重大科技专项项目

(编号:2009ZDKG73)

12. 基于计算机三维模拟技术研究人乳腺癌微血管构筑表型异质性

2010高等学校博士学科点专项科研基金

(编号:20100201110059)

13. miRNA对三阴性乳腺癌细胞可塑性和血管生成拟态形成的调控及其分子机制研究

2012年吴阶平医学基金会临床科研专项资助基金

(编号:320.6750.12355)

14. 西北地区生存环境、生活习惯与肿瘤发生发展及转化医学研究项目组骨干成员

教育部“创新团队发展计划资助”(PCSIRT:1171)2012-2014年

学术及科研成果、专利、论文

1. Li C, Zhao Z, Zhou J, Liu Y, Wang H, Zhao X*. Relationship between the TERT, TNIP1 and OBFC1 genetic polymorphisms and susceptibility to colorectal cancer in Chinese Han population. Oncobarget,2017,8(34):56932-56941.SCI 收录(IF=5.168)

2. Wang G, Li J, Zhang L, Huang S, Zhao X, Zhao X*. Celecoxib induced apoptosis against different breast cancer cell lines by down-regulated NF-κB pathway. Biochem Biophys Res Commun. 2017,26;490(3):969-976.SCI 收录(IF=2.466)

3. Wang G, Yuan N, Huang S, Feng L, Han R, Zhang Y, Ren J, Meng M, Zhao X*.The CNGRCLLII(KLAKLAK)2 peptide shows cytotoxicity against HUVECs by inducing apoptosis: An in vitro and in vivo study.Tumour Biol, 2017,39(5):1010428317701649.SCI 收录(IF=3.65)

4. Luo M, Huang H, Hou L, Shao S, Huang S, Zhao X*. Construction and expression of a lentivirus expression vector carrying the VEGF165-EGFP fusion gene in breast cancer MCF-7 cells. Oncol Lett, 2017,13(3):1745-1752. SCI 收录(IF=1.39)

5. Yue C, Li M, Da C, Meng H, Lv S, Zhao X*. Association between genetic variants and esophageal cancer risk.Oncotarget. 2017,8(29):47167-47174. SCI 收录(IF=5.168)

6. Luo M, Hou L, Li J, Shao S, Huang S, Meng D, Liu L, Feng L, Xia P, Qin T, Zhao X*. VEGF/NRP-1 axis promotes progression of breast cancer via enhancement of   epithelial-mesenchymal transition and activation of NF-kB and β-catenin. Cancer Lett,2016,373(1):1-11. SCI收录(IF=5.992)

7. Li X, Zou W, Liu M, Cao W, Jiang Y, An G, Wang Y, Huang S, Zhao X*. Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population. Oncotarget, 2016, doi: 10.18632/oncotarget.13402. SCI 收录(IF=5.008)

8. Wu F, Liu Y, Li J, Hou L, Lei F, Huang S, Feng L, Zhao X*. Human serum albumin-mediated apoptin delivery suppresses breast cancer cell growth in vitro and in vivo. Oncol Lett, 2017, 13(2):579-586. SCI 收录(IF=1.482)

9. Han R, Wang G, Zhang Y, Zhao X*. Efficacy of neoadjuvant chemotherapy combined with bevacizumab versus neoadjuvant chemotherapy alone for Her2-negative breast cancer: a meta-analysis of randomized controlled clinical trials. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2016, 45(4):379-386. MI 收录

10. Shao S, Zhao X, Zhang X, Luo M, Zuo X, Huang S, Wang Y, Gu S*, Zhao X*. Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner. Mol Cancer, 2015,14:28. SCI收录(IF=5.888)

11. Wang T, Shigdar S, Gantier MP, Hou Y, Wang L, Li Y, Shamaileh H, Yin W, Zhou SF, Zhao X*, Duan W*. Cancer stem cell targeted therapy: progress amid controversies. Oncotarget, 2015,6(42):44191-206. SCI 收录(IF=5.008)

12. Zuo X, Chen L, Liu L, Zhang Z, Zhang X, Yu Q, Feng L, Zhao X*, Qin T*. Identification of a panel of complex autoantigens (LGALS3, PHB2, MUC1, and GK2) in combination with CA15-3 for the diagnosis of early-stage breast cancer. Tumor Biol, 2016, 37(1):1309-1317. SCI 收录(IF=2.926)

13. Zhang X, Zhao X, Shao S, Zuo X, Ning Q, Luo M, Gu S*, Zhao X*. Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenotype in breast cancer cells and STAT3 plays a key role. Int J Oncol, 2015, 46(3):1141-1148. SCI收录(IF=3.018)

14. Zhang Z, Hou L, Feng L, Huang S, Luo M, Shao S, Zhang X, Gu S, Zhao X*.An antimicrobial peptide containing NGR motif has potent antitumor activity against CD13+ and CD13− tumor cells. Tumor biol, 2015, 36(10):8167-8175. SCI 收录(IF=2.926)

15. Zhao Y, Yuan NA, Li K, Geng YI, Zhou H, Wang H, Hou J, Zhang B, Cai Y, Zhao X*. Bilateral breast cancer following augmentation mammaplasty with polyacrylamide hydrogel injection: A case report. Oncol Lett,2015, 9(6):2687-2693. SCI 收录(IF=1.482)

16. Meng D, Liu R, Pei L, Hou L, Ning Q, Yu Q, Feng L, Zhao X*. Lentivirus Vector-mediated Gene Transfection of CNGRC Peptide in Rat Adipose Stem Cells. Mol Med Rep, 2015, 11(4): 2555-2561. SCI 收录(IF=1.559)

17. Liu L, Hou L, Gu S*, Zuo X, Meng D, Luo M, Zhang X, Huang S, Zhao X*.Molecular mechanism of pigallocatechin-3-gallate in human esophageal squamous cell carcinoma in vitro and in vivo. Oncol Rep, 2015, 33(1): 297-303. SCI 收录(IF=2.486)

18. Wu F, Zhao X, Mi B, Feng Lu, Yuan NA, Lei F, Li M, Zhao X*. Clinical characteristics and prognostic analysis of Krukenberg tumor. Mol Clin Oncol, 2015,3(6):1323-1328.

19. Zuo X, Qin Y, Zhang X, Ning Q, Shao S, Luo M, Yuan N, Huang S, Zhao X*. Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI. Oncol Rep, 2014, 31(5): 2358-2364. SCI 收录(IF=2.486)

20. Yuan N, Meng M, Liu C, Feng L, Hou L, Ning Q, Xin G, Pei L, Gu S*, Li X, Zhao X*. Clinical characteristics and prognostic analysis of triple negative breast cancer patients. Mol Clin Oncol, 2014, 2(2): 245-251.

21. Liu C, Zhao X, Zhao Z, Lu P, Jin F, Li G. Malignant Inflammatory Myofibroblastic Tumor of the Prostate. J Clin Oncol, 2013, 31(10):e144-7. SCI 收录(IF=20.982)

22. Ning Q, Liu C, Hou L, Meng M, Zhang X, Luo M, Shao S, Zuo X, Zhao X*. Vascular endothelial growth factor receptor-1 activation promotes migration and invasion of breast cancer cells through epithelial-mesenchymal transition. PLoS One,2013, 8(6):e65217. SCI 收录(IF=3.057)

23. Hou L, Zhao X*, Wang P, Ning Q, Meng M, Liu C. Antitumor activity of antimicrobial peptides containing CisoDGRC in CD13 negative breast cancer cells. PLoS One, 2013, 8(1): e53491. SCI 收录(IF=3.057)

24. Meng M, Zhao X, Dang Y, Ma J, Li L, Gu S*. Region-specific expression of brain-derived neurotrophic factor splice variants in morphine conditioned place preference in mice. Brain Res, 2013, 1519:53-62. SCI 收录(IF=2.561)

25. Xin G, Zhao X*, Duan X, Ning Q, Meng M, Meng D, Liu L. Antitumor effect of a generation 4 polyamidoamine dendrimer/cyclooxygenase-2 antisense oligodeoxynucleotide complex on breast cancer in vitro and in vivo. Cancer Biother Radiopharm, 2012, 27(1):77-87. SCI 收录(IF=1.715)

26. Ning Q, Hou L, Meng M, Pan BR, Zhao XH*. TNF related apoptosis -inducing ligand and its receptors in ocular tumors. Int J Ophthalmol, 2011, 4(5):552-557. SCI 收录(IF=0.939)

27. Wang P, Zhao XH*, Wang ZY, Meng M, Li X, Ning Q. Generation 4 polyamidoamine dendrimers is a novel candidate of nano-carrier for gene delivery agents in breast cancer treatment. Cancer Lett, 2010, 298(1):34-49. SCI 收录(IF=5.992)

28. Meng M, Zhao XH*, Ning Q, Hou L, Xin GH, Liu LF. Tumor stem cells: A new approach for tumor therapy. Oncol Lett, 2012, 4(2): 187-193.  SCI 收录(IF=1.482)

29. Xin GH, Zhao XH*, Liu D, Gong Q, Hou L, Li JY, Pan BR, Li X and Cheng YJ. Effect of VEGF-targeted antisense gene therapy on retinoblastoma cell line SO-RB50 in vitro and in vivo. Int J Ophthalmol, 2012, 5(4): 440-447. SCI 收录(IF=0.939)

30. Qin TJ, Ma W, Liu SX, Yang GX, Wang QY, Zhao XH*. Secretory expression of Par-4 SAC-HA2TAT following adeno-associated virus-mediated gene transfer induces apoptosis in HepG2 cells. Mol Med Rep, 2010, 3(5):749-757. SCI 收录(IF=1.559)

31. Gu SZ, Zhao XH*, Zhang LX, Li L, Wang ZY, Meng M, An GL. Anti-angiogenesis effect of generation 4 polyamidoamine/vascular endothelial growth factor antisense oligodeoxynucleotide on breast cancer in vitro. J Zhejiang Univ Sci B, 2009, 10(3):159-167.  SCI 收录(IF=1.303)

32. Qin TJ, Zhao XH*, Yun J, Zhang LX, Ruan ZP, Pan BR. Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma. World J Gastroenterol, 2008, 14(33):5210-5216. SCI 收录(IF=2.787)

33. Zhao X, Li L, Wang Z. Chemoprevention of breast cancer: current status and future prospects. Front Biosci, 2006, 11:2249-2256.  SCI 收录(IF=2.484)

34. Zhao X, Tian H, Ma X, Li L. Epigallocatechin gallate, the main ingredient of green tea induces apoptosis in breast cancer cells. Front Biosci, 2006, 11:2428-2433. SCI 收录(IF=2.484)

35. Gu SZ, Zhao XH*, Quan P, Li SB, Pan BR. Alterations of serum cholinesterase in patients with gastric cancer. World J Gastroenterol, 2005, 11(29):4604-4606. MI 收录

36. Zhao XH, Gu SZ, Tian HG, Quan P, Pan BR. Clinical significance of expression of apoptotic signal proteins in gastric carcinoma tissue. World J Gastroenterol, 2005, 11(25):3846-3849. MI 收录

37. Zhao XH, Gu SZ, Liu SX, Pan BR. Expression of estrogen receptor and estrogen receptor messenger RNA in gastric carcinoma tissues. World J Gastroenterol, 2003, 9(4):665-669. SCI 收录(IF=3.318)

联系方式
电子邮箱:zhaoxinhan@mail.xjtu.edu.cn
联系电话:029-85324136,13909240672
联系地址:雁塔西路277号西安交大一附院
更新日期:2020-04-20