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封卫毅 |
1. 骨髓源性细胞与血管新生的关系
2. 血管新生与糖尿病并发症的关系及药物干预研究
3. 相关的药物作用靶点及新药、新制剂研究
主持国家自然科学基金项目2项
《低剂量/预给药条件下化疗药物显现促肿瘤生长转移作用的机制研究》
《骨髓源性细胞中促肿瘤血管新生细胞亚群的研究》
主持教育部留学归国人员基金项目1项
《骨髓源性细胞在药物影响血管新生过程的作用研究》
主持陕西省自然科学项目1项
《骨髓源性细胞在雌激素调节肿瘤血管新生中作用研究》
主持陕西省科技攻关项目1项
《中药促进血管新生有效成分筛选及关键技术研究》
主持十一五国家科技重大专项重大新药创制项目子项目1项
《基因重组血管生长抑制剂Kringle5的中试生产工艺和药用研究》药效学研究
陕西省中医药管理局中医药科研课题1项
《当归补血汤促血管新生作用的物质基础及机制研究》
1. GM-CSF increases tumor growth and angiogenesis directly by promoting endothelial cell function and indirectly by enhancing the mobilization and recruitment of proangiogenic granulocytes. Tumor Biology. (accepted)
2. The effects of gliclazide, methylcobalamin, and gliclazide plus methylcobalamin combination therapy on diabetic peripheral neuropathy in rats. Life Science. 2016;16:60-68
3. Evaluation of adverse health risks associated with antineoplastic drug exposure in nurses at two Chinese hospitals: The effects of implementing a pharmacy intravenous admixture service. Am J Ind Med. 2016;59(4):264-73.
4. Vasorelaxant Activities of Danhong Injection and Their Differential Effects on the Rat Abdominal Aorta and Mesenteric Artery. Journal of Cardiovascular Pharmacology. 2015, 65(1): 62-71.
5. A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing. Blood. 2011;117(14):3893-3902.
6. The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells. J. Cell Biology. 2008,183(12): 1145-1157
7．Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ Res. 2007, 14;101(6):570-80
8. Integrin signaling is critical for pathological angiogenesis. J Exp Med. 2006,203(11):2495-507
