 |
武淑芳 |
1.2017年1月-2020年12月, 国家自然科学基金面上项目。“Sirt1 对软骨内成骨及软骨稳态维持的调控机制研究”。项目负责人。
2.2015年1月-2018年12月, 国家自然科学基金面上项目。“外周生物钟紊乱在生长激素不敏感状态软骨功能异常的作用机制研究”。项目负责人。
3.2013年1月-2015年12月, 国家自然科学基金“优秀青年科学基金”项目。“自噬调节在软骨功能障碍相关疾病的作用机制研究”。项目负责人。
4.2011年1月-2013年12月, 国家自然科学基金面上项目。“FGF21介导“生长激素不敏感状态”软骨发育迟滞的机制研究”。项目负责人。
5.2010年1月-2013年12月，国家自然科学基金重点项目。第三参加人。
6.2012年1月-2014年12月，教育部新世纪优秀人才支持计划。项目负责人。
7.西安交通大学国家“985”创新研究基地方向项目。项目名称：“生长激素不敏感类似状态”软骨发育调控关键蛋白网络的鉴定。项目负责人。
1. Kang X, Yang W, Feng D, Jin X, Ma Z, Qian Z, Xie T, Li H, Liu J, Wang R, Li F, Li D, Sun H*, Wu S (通讯作者，西安交通大学)*. Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner. J Bone Miner Res. 2017 Oct; 32(10):2128-2141.
2. Yang W, Kang X, Liu J, Li H, Ma Z, Jin X, Qian Z, Xie T, Qin N, Feng D, Pan W, Chen Q, Sun H*, Wu S (通讯作者，西安交通大学)*. Clock gene Bmal1 modulates human cartilage gene expression by crosstalk with Sirt1. Endocrinology 2016, 157(8):3096-107.
3. Zhou B, Li H, Liu J, Xu L, Guo Q, Zang W, Sun H*, Wu S(通讯作者，西安交通大学)*. Autophagic Dysfunction is Improved by Intermittent Administration of Osteocalcin in Obese Mice. International Journal of Obesity (Lond) 2016, May 40(5):833-43.
4. Wu S (西安交通大学), Yang W, De Luca F. Insulin-like growth factor independent effects of growth hormone on growth plate chondrogenesis and longitudinal bone growth. Endocrinology. 2015 Jul; 156(7):2541-51.
5. Li H, Zhou B, Liu J, Li F, Li Y, Kang X, Sun H*, Wu S (通讯作者，西安交通大学)*. Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner. Cell Cycle. 2015;14(12):1893-907.
6. Liu J, Li H, Zhou B, Xu L, Kang X, Yang W, Wu S (通讯作者，西安交通大学)*, Sun H*. PGRN Induces Impaired Insulin Sensitivity and Defective Autophagy in Hepatic Insulin Resistance. Mol Endocrinol. 2015 Apr;29(4):528-41.
7. Li H, Zhou B, Xu L, Liu J, Zang W, Wu S (通讯作者，西安交通大学)*, Sun H*. Circulating PGRN Is Significantly Associated With Systemic Insulin Sensitivity and Autophagic Activity in Metabolic Syndrome. Endocrinology. 2014;155(9):3493-507.
8. Wu S (西安交通大学), Grunwald T, Kharitonenkov A, Dam J, Jockers R, De Luca F. Increased expression of Fibroblast Growth Factor 21 (FGF21) during chronic undernutrition causes Growth Hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression. Journal of Biological Chemistry. 2013, 288(38):27375-83
9. Li H, Zhou B, Xu L, Liu J, Zang W, Wu S (通讯作者，西安交通大学)*, Sun H*. The Reciprocal Interaction between Autophagic Dysfunction and ER stress in Adipose Insulin Resistance. Cell Cycle. 2014;13(4):565-79.
10.Wu S, Levenson A, Kharitonenkov A, De Luca F. Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate. Journal of Biological Chemistry. 2012, 287(31): 26060-7.
11.Wu S (通讯作者，西安交通大学), Zang W, Li X, Sun H. Proepithelin Stimulates Growth Plate Chondrogenesis via Nuclear Factor-kappaB-p65-dependent Mechanisms. Journal of Biological Chemistry. 2011, 286(27): 24057-67.
12.Wu S, Morrison A, Sun H, De Luca F. Nuclear Factor-{kappa}B (NF-{kappa}B) p65 Interacts with Stat5b in Growth Plate Chondrocytes and Mediates the Effects of Growth Hormone on Chondrogenesis and on the Expression of Insulin-like Growth Factor-1 and Bone Morphogenetic Protein-2. Journal of Biological Chemistry. 2011, 286(28):24726-34.
13.Wu S, Aguilar A, Ostrow V, De Luca F. Insulin resistance secondary to a high-fat diet stimulates longitudinal bone growth and growth plate chondrogenesis in mice. Endocrinology. 2011, 152(2): 468-475.
14.Wu S, Walenkamp MJ, Lankester A, De Luca F. Growth Hormone (GH) and Insulin-like growth Factor-I (IGF-I) insensitivity of fibroblasts isolated from a patient with a IkB α mutation. The Journal of Clinical Endocrinology & Metabolism. 2010, 95:1220-1228.
15.Aguilar A*, Wu S*(并列第一作者，西安交通大学), De Luca F. P450 oxidoreductase (POR) expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian hedgehog (Ihh)-dependent mechanisms. Endocrinology. 2009,150: 2732-2739.
16.Wu S, Fadoju D, Rezvani G, De Luca F. The stimulatory effects of Insulin-like growth factor-1 on growth plate chondrogenesis are mediated by nuclear factor-kB p65. Journal of Biological Chemistry. 2008, 283: 34037-34044.
17.Wu S, Flint JK, Rezvani G, De Luca F. Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis. Journal of Biological Chemistry. 2007, 282(46): 33698-706.
18.Wu S, Yuji Yoshiko, De Luca F. Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis. Journal of Biological Chemistry. 2006, 281(8): 5120-7.
19.Wu S, De Luca F. Inhibition of the proteasomal function in chondrocytes down-regulates growth plate chondrogenesis and longitudinal bone growth. Endocrinology. 2006, 147(8): 3761-3768.
20.Wu S, Palese T, Mishra OP, Delivoria-Papadopoulos M, De Luca F. Effects of Ca2+ sensing receptor activation in the growth plate. FASEB Journal. 2004, 18(1): 143-5.
21.Wu S, De Luca F. Role of Cholesterol in the regulation of Growth Plate Chondrogenesis and Longitudinal Bone Growth. Journal of Biological Chemistry. 2004, 6: 279(6): 4642-7.
