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陈葳  
研究领域（方向）

1.肿瘤相关长链非编码RNA筛选与功能研究

2.临床分子诊断技术

个人及工作简历

1985年获得西安医科大学医学学士学位

1990年获得西安医科大学生物化学专业硕士学位

2006年获得西安交通大学病理与病理生理学博士学位

1985.7-1987.9西安医科大学克山病研究室实习研究员

1990.7-1993.9西安医科大学中西医结合研究所助理研究员

1993.9-2001.10西安交通大学第一附属医院分子医学中心副研究员

2001.10-2010.10西安交通大学第一附属医院检验科主任技师

科研项目

主持基金：

1.人膀胱癌侵袭相关基因的分离与鉴定 国家自然科学基金2004-2006 项目编号：30370660

2.非编码RNA-UCA1启动子转录调控及其在肿瘤增殖中的作用国家自然科学基金 2011-2013 项目编号：81072104

3.LncRNA-UCA1通过糖酵解途径调控膀胱癌细胞自噬的机制国家自然科学基金 2016-2019 项目编号：81572735

4.UCA1结合hnRNP I/L参与膀胱癌细胞谷氨酰胺依赖的三羧酸循环回补机制国家自然科学基金 2018-2021 项目编号：81772735


学术及科研成果、专利、论文

获奖情况：

陈葳（2/6）,热休克蛋白70和糖调节蛋白96在消化道肿瘤中的表达及其免疫佐剂功能的研究，陕西省科技厅，二等奖，2015

获批专利：

陈葳，一种与子宫内膜癌相关的长非编码RNA及其siRNA和应用，2016.6.1，中国，ZL201410166296.4

发表论文：（通讯作者）

  1. Bao-Lin Li, Xin-min Li, Si-Jian, Luo, Zhang-Rui, Zeng, Xue-Jing Xu, Xin-yu, Li, Song-zhi, Zhang, Yi-Rong, Chen, Shijia Ding, Jin-Bo Liu, Wei Chen*.Enzyme-Accelerated Catalytic DNA Circuits Enable Rapid and One-pot Detection of Bacterial Pathogens[J].Biosens Bioelectron. 2025 Jan 1:267:116822.

  2. Shan-Shan Liu, Jia-Shu Li, Mei Xue, Wen-Jing Wu, Xu Li,Wei Chen*.LncRNA UCA1 Participates in De Novo Synthesis of Guanine Nucleotides in Bladder Cancer by Recruiting TWIST1 to Increase IMPDH1/2[J].Int J Biol Sci. 2023 May 8;19(8):2599-2612.

  3. Kexin Sun, Tingting Lu, Cheng Hu, Zhengyi Li, Jie Zhu, Li Zhang, Xiaotong Shao,Wei Chen*.LINC00115 regulates lung adenocarcinoma progression via sponging miR-154-3p to modulate Sp3 expression[J].Mol Cell Probes.2023 Apr:68:101909.

  4. Hua Zhao, Wenjing Wu, Xu Li, Wei Chen*.Long noncoding RNA UCA1 promotes glutamine-driven anaplerosis of bladder cancer by interacting with hnRNP I/L to upregulate GPT2 expression[J].Transl Oncol. 2022 Mar:17:101340.

  5. Jingzhang Ji, Jialyu Tang, Ping Ren, Wenpin Cai, Meina Shen, Qiunan Wang, Xiaoyun Yang,Wei Chen*.Downregulation of circLIFR exerts cancer-promoting effects on hepatocellular carcinoma in vitro[J].Front Genet. 2022 Sep 12:13:986322.

  6. Yan Li, Yu Pang, Tianhua Zhang, Xiaoping Xian, Jian Yang, Rui Wang, Panting Wang, Meng Zhang, Wei Chen*.Genotypes of Mycobacterium tuberculosis isolates circulating in Shaanxi Province, China[J].PLoS One. 2020 Dec 3;15(12):e0242971.

  7. You-Jie Li, Yun-Xiao Sun , Rui-Min Hao , Pin Wu , Li-Jun Zhang , Xu Ma , Ying Ma , Ping-Yu Wang , Ning Xie , Shu-Yang Xie ,Wei Chen*. miR-33a-5p enhances the sensitivityof lung adenocarcinoma cells to celastrol by regulatingmTOR signaling[J].Int J Oncol. 2018 ,52(4):1328-1338.

  8. Linchuan Wang, Xu-Dong Tian, Yan Yu, Wei Chen*.Evaluation of the performance of two tuberculosis interferon gamma release assays  (IGRA-ELISA and T-SPOT.TB) for diagnosing Mycobacterium tuberculosis infection[J].Clin Chim Acta. 2018,479:74-78. 

  9. Wang L, Zhou KH, Zhao HP, Wang JH, Zheng HC, Yu Y, Chen W*. The characteristics of screening and confirmatory test results for HIV in Xi'an, China[J].PLoS One.2017,12(7):e0180071.

  10. Xie Xiaojuan, Pan Jingjing, Wei LiQiang, Wu Shouzhen, Hou Huilian, Li Xu, Chen Wei*. Gene expression profiling of microRNAs associated with UCA1 in bladder cancer cells[J]. International Journal of Oncology, 2016, 48(4):1617-27.

  11. Pan Jingjing, Li Xu, Wu Wenjing, Xue Mei, Hou Huilian, Zhai Wen, Chen Wei*. Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells[J]. Cancer Letters, 2016, 382: 64-76.

  12. Xue Mei, Pang Huan, Li Xu, Li Huijin, Pan Jingjing, Chen Wei*.Long non‐coding RNA urothelial cancer‐associated 1 promotes bladder cancer cell migration and invasion by way of the hsa‐miR 145–ZEB1/2–FSCN1 pathway[J].Cancer Sci. 2016 ,107(1): 18–27.

  13. Yang Chao, Li Zhuo, Wei Kang, Chen Wei*. TET1 and TET3 are essential in induction of Th2-type immunity partly through regulation of IL-4/13A expression in zebrafish model[J]. Gene, 2016, 591(1):201-208

  14. Xue Mei, Li Xu, Chen Wei*, Hypoxia regulates CCAAT/enhancer binding protein α expression and localization mediated by hypoxia inducible factor-1α in bladder transitional carcinoma cells[J]. Mol Med Rep, 2015, 12(2): 2121-2127

  15. Li Huijin, Li Xu, Pang Huan, Pan Jingjing, Xie Xiaojuan, Chen Wei*. Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer[J]. Japanese Journal of Clinical Oncology. 2015, 45(11):1055 -1063.

  16. Zhai Wen, Li Xu, Wu Shouzhen, Chen Wei*. Microarray expression profile of lncRNAs and the upregulated ASLNC04080 lncRNA in human endometrial carcinoma.[J]. International Journal of Oncology, 2015, 46(5):2125.

  17. Li Huijin, Chen Wei*. Role of microRNAs in the Warburg effect and mitochondrial metabolism in cancer.[J]. Asian Pacific Journal of Cancer Prevention Apjcp, 2014, 15(17):7015-7019.

  18. Xue Mei, Li Xu, Wu Wenjing, Zhang Shuwan, Wu Shouzhen, Li Zhengkun, Chen Wei*, Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein alpha contributes to bladder cancer cell growth and reduced apoptosis[J]. Oncol Rep, 2014, 31(5): 1993-2000.

  19. Xue Mei, Li Xu，Li Zhengkun，Chen Wei*, Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1 alpha-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion[J]. Tumour Biol, 2014, 35 (7): 6901-6912.

  20. Li Zhenken, Li Xu, Wu Shouzhen, Xue Mei, Chen Wei*. Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway[J]. Cancer Sci, 2014, 105(8): 951-955.

  21. Wu Wenjing, Zhang Shuwan, Li Xu, Xue Mei, Cao Sancheng, Chen Wei*. Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells[J]. PLoS One. 2013 Sep 12;8(9):e73920.

  22. Zuo Qinqin, Wu Wenjing, Li Xu, Zhao Le, Chen Wei*, HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin[J]. Oncol Rep, 27(3), 819-824, 2012.

  23. Yang Chen, Li Xu, Wang Yu, Zhao Le, Chen Wei*. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells[J]. Gene. 2012 Mar 15;496(1):8-16.

  24. Wang Fan, Li Xu, Xie Xiaojuan, Zhao Le, Chen Wei*. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion[J]. FEBS Lett. 2008 Jun 11;582(13):1919-27.p>

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更新日期：2025-02-19