教师内容页
刘新社 |
研究领域(方向)
1.脑神经疾病的分子机制 2.法医学 3. 成瘾药物体内代谢分析与中药戒毒;4.药物人体内痕量检测分析技术
个人及工作简历
1987.7-1994.6西安医科大学法医系,任助教
1994.6-2001.6西安交通大学法医系,任讲师
2001.6-2014.12西安交通大学法医系,任副教授
2014.12-至今西安交通大学医学部法医学院,任教授
科研项目
1.用D1敲除小鼠模型研究fos转录因子在MA依赖中的调控作用(教育部留学回国启动基金 08回国基金01)
2.Fos 转录因子泛素化在甲基安非他命依赖中的调控作用(陕西省自然科学基金SJ08C226)
3.△FosB 稳定性机制在甲基苯丙胺慢性成瘾中的调控作用(国家自然科学基金30973366)
4.ΔFosB 及其上游信号转导通路的调控机制及其人工干预对MA 慢性依赖小鼠行为学变化的影响(国家自然科学基金81273351)
5.MA成瘾相关通路中ΔFosB作用机制的研究 (陕西省科学技术研究发展计划项目2012kw-36-02)
6.基于microRNAs与Glu-NMDAR神经递质系统在甲基苯丙胺依赖中的分子机制研究(国家自然科学基金81471818)
7.伏隔核多巴胺D3受体与NMDA受体相互作用参与吗啡行为敏化的分子机制(国家自然科学基金81373253)
学术及科研成果、专利、论文
1992年开始医疗事故法律制度模型的研究,先后发表相关论文20余篇,主编及参编医疗事故专著各一本。1999年攻读博士学位期间开始了人类DNA遗传多态性的研究,先后参加了《人类基因组计划中国1%项目》等重大科研项目,博士学位课题《线粒体DNA HVSⅠ序列多态性及其法医学应用的研究》为我系后续的线粒体DNA多态性的研究建立了平台; 2005年5月至2006年8受国家留学基金委资助,赴美国加州大学戴维斯分校MIND研究所做博士后研究,师从美国著名神经科学专家Frank Sharp教授,开展了神经系统蛋白质转录调控方面的研究,回国后一直开展毒品代谢、分析、药物依赖机制及中药戒毒方面的研究。
以第一或通信作者发表的代表论文:
1. Fanglin Guan, Lu Li, Chuchu Qiao, Gang Chen, Tinglin Yan, Tao Li, Tianxiao Zhang& Xinshe Liu. Evaluation of genetic susceptibility of common variants in CACNA1D with schizophrenia in Han Chinese. Sci. Rep. 5, 12935; doi: 10.1038/srep12935 (2015). (SCI, IF=5.780(2014)
2.Fanglin Guan; Shuguang WeiChen ZhangHongbo Zhang; Bao Zhang; Bo Xing; Zufei Feng; Chengge GaoXinshe LiuShengbin Li, 2013, A population-based association study of 2q32.3 and 8q21.3 loci with schizophrenia in Han Chinese, Journal of Psychiatric Research, 47(6), pp 712-717 (SCI, IF=4.066(2012))
3. Fanglin Guan; Bo Zhang; Tinglin Yan; Lu Li; Fei Liu; Tao Li;Zufei Feng; Bao Zhang;Xinshe Liu,Shengbin Li, 2013, MIR137 gene and target gene CACNA1C of miR-137 contribute to schizophrenia susceptibility in Han Chinese, Schizophrenia Research, (SCI, IF=4.590(2012))
4. Yan, Tinglin; Li, Lu; Sun, Baiyu; Liu, Fei; Yang, Peng; Chen, Teng; Li, Tao; Liu, Xinshe Luteolin inhibits behavioral sensitization by blocking methamphetamine-induced MAPK pathway activation in the caudate putamen in mice. PloS one,2014, 9(6)e98981 (SCI, IF=3.730(2012), Citation=1)
5. Xinshe Liu et.al.Dopamine D3 Receptor-Regulated NR2B Subunits of N-Methyl-D-Aspartate Receptors in the Nucleus Accumbens Involves in Morphine-Induced Locomotor Activity.2014,CNS Neuroscience & Therapeutics. 20(9):823-9(SCI, IF=3.730(2014)
6. Zhu, Bo-feng; Shen, Chun-mei; Wang, Hong-dan; Yang, Guang; Yan, Jiang-wei; Qin, Hai-xia; Guo, Jian-xin; Huang, Jing-feng; Jing, Hang; Liu, Xin-she, 2011, Genetic diversities of 21 non-CODIS autosomal STRs of a Chinese Tibetan ethnic minority group in Lhasa, International Journal of Legal Medicine, 125(4), pp 581-585 (SCI, IF=2.5870(2011), Citation=13)
以第一或通信作者发表的代表论文:
1. Fanglin Guan, Lu Li, Chuchu Qiao, Gang Chen, Tinglin Yan, Tao Li, Tianxiao Zhang& Xinshe Liu. Evaluation of genetic susceptibility of common variants in CACNA1D with schizophrenia in Han Chinese. Sci. Rep. 5, 12935; doi: 10.1038/srep12935 (2015). (SCI, IF=5.780(2014)
2.Fanglin Guan; Shuguang WeiChen ZhangHongbo Zhang; Bao Zhang; Bo Xing; Zufei Feng; Chengge GaoXinshe LiuShengbin Li, 2013, A population-based association study of 2q32.3 and 8q21.3 loci with schizophrenia in Han Chinese, Journal of Psychiatric Research, 47(6), pp 712-717 (SCI, IF=4.066(2012))
3. Fanglin Guan; Bo Zhang; Tinglin Yan; Lu Li; Fei Liu; Tao Li;Zufei Feng; Bao Zhang;Xinshe Liu,Shengbin Li, 2013, MIR137 gene and target gene CACNA1C of miR-137 contribute to schizophrenia susceptibility in Han Chinese, Schizophrenia Research, (SCI, IF=4.590(2012))
4. Yan, Tinglin; Li, Lu; Sun, Baiyu; Liu, Fei; Yang, Peng; Chen, Teng; Li, Tao; Liu, Xinshe Luteolin inhibits behavioral sensitization by blocking methamphetamine-induced MAPK pathway activation in the caudate putamen in mice. PloS one,2014, 9(6)e98981 (SCI, IF=3.730(2012), Citation=1)
5. Xinshe Liu et.al.Dopamine D3 Receptor-Regulated NR2B Subunits of N-Methyl-D-Aspartate Receptors in the Nucleus Accumbens Involves in Morphine-Induced Locomotor Activity.2014,CNS Neuroscience & Therapeutics. 20(9):823-9(SCI, IF=3.730(2014)
6. Zhu, Bo-feng; Shen, Chun-mei; Wang, Hong-dan; Yang, Guang; Yan, Jiang-wei; Qin, Hai-xia; Guo, Jian-xin; Huang, Jing-feng; Jing, Hang; Liu, Xin-she, 2011, Genetic diversities of 21 non-CODIS autosomal STRs of a Chinese Tibetan ethnic minority group in Lhasa, International Journal of Legal Medicine, 125(4), pp 581-585 (SCI, IF=2.5870(2011), Citation=13)
联系方式
电子邮箱:lxins@mail.xjtu.edu.cn