主要从事天然药物化学的研究与开发。主要是从中草药、药用植物、微生物等天然药物资源中寻找结构新颖、活性显著的天然产物，并以此为先导化合物，通过化学结构改造和优化等方法从中发现高效低毒的前药分子。

2021.7-至今 西安交通大学，药学院，副教授

2017.7-2021.6 西安交通大学，药学院，讲师

2012.9-2017.6 华中科技大学，同济药学院，博士

2008.9-2012.6 江苏大学，药学院，学士

1、国家自然科学基金面上项目, No. 32570461, 2026-01至2029-12, 50万元，主持

2、国家自然科学基金面上项目, No. 32270412, 2023-01至2026-12, 54万元,主持

3、陕西省中医药中青年骨干人才支持计划, No. TZKN-CXRC-03, 2025-01至2026-12, 20万元, 主持

4、陕西省重点研发计划（四链融合项目），No. 2024CY-JJQ-03，2025-01至2026-12，40万元，合作单位主持人

5、咸阳市重大科技创新专项，No. L2024-ZDKJ-ZDGG-NY-0011，2025-01至2027-12，40万元，合作单位主持人

6、国家自然科学基金青年项目, No. 31800286, 2019-01至2021-12, 25万元, 主持

7、陕西省重点研发计划（一般项目）, No. 2023-YBSF-187, 2023-01至2024-12, 6万元,主持

8、陕西省中医药管理局, 中医药传承创新暨“秦药”开发重点科学研究项目, No. 2021-02-ZZ-018, 2021-10至2023-10, 10万元, 主持

9、中央高校基本科研业务费, No. xpt012022038, 2022-01至2022-12, 10万元, 主持

10、中国博士后基金面上项目, No. 2021M702636, 2021-09至2023-08, 8万元, 主持

11、陕西省自然科学基础研究计划项目, No. 2019JQ-194, 2019-01至2020-12, 3万元,主持

12、中国博士后基金面上项目, No. 2017M623200, 2017-07至2020-06, 5万元, 主持

13、中央高校基本科研业务费, No. xjj2018169, 2018-01至2020-12, 15万元, 主持

14、西安交通大学新讲师支持计划, No. xjj2017060, 2018.01-2021.12, 10万元, 主持

(1)    Zhetong Liu#, Tao Yang#; Xiaozhi Huang, Qing Qi, Chending Luo, Nan Wang, Yujiao Shu, Hui Zhang, Guanqun Zhan*, Zengjun Guo*. Spiropenicitrinol A: a spirocyclic polyketide from Penicillium citrinum with potent anti-inflammatory activity. Organic Letters, 2026, 28, 4457-4461.

(2)    Kailing Yang, Nan Wang, Rongkun Miao, Chending Luo, Xiaozhi Huang, Qing Qi, Fangru Guo, Guanqun Zhan*, Zengjun Guo*, Diverse monoterpene indole alkaloids with unprecedented chemical architectures from Rauvolfia vomitoria and their potential as cisplatin sensitizers. The Journal of Organic Chemistry, 2026, 91, 8950-8958.

(3)    Kailing Yang, Zhetong Liu, Xueqing Ma, Nan Wang, Qing Qi, Xiaozhi Huang, Guanqun Zhan*, Zengjun Guo*. Cisplatin-synergistic monoterpene indole alkaloids with diverse scaffolds from Rauvolfia vomitoria. Bioorganic Chemistry, 2026, 180, 110120.

(4)    Kailing Yang, Yu Zhang, Rongkun Miao, Chending Luo, Xiaoxiao Yuan, Xueqing Ma, Nan Wang, Guanqun Zhan*, Zengjun Guo*. SMART-guided discovery of Sarpagine-type monoterpene indole alkaloids from Rauvolfia vomitoria and the synergistic effects with cisplatin against human ovarian cancer cells. Bioorganic Chemistry, 2026, 168, 109284.

(5)    Kailing Yang, Zhetong Liu, Chending Luo, Saisai Xin, Xiaozhi Huang, Qing Qi, Guanqun Zhan*, Zengjun Guo*. Cytotoxic spirocyclic polyketides and γ-lactones from endophytic fungus Talaromyces purpureogenus Y21 guided by molecular networking and SMART strategies. Phytochemistry, 2026, 250, 114968.

(6)    Guanqun Zhan#, Fuxin Zhang#, Kailing Yang, Tao Yang, Ruixi Zhou, Xueqing Ma, Nan Wang, Zengjun Guo,* Polycyclic pyrroloindoline-containing natural products with a unique 3-heptyl-2a,4a-diazapentaleno[1,6-ab]indene core isolated from Alstonia scholaris, Organic & Biomolecular Chemistry, 2024, 22, 296-301.

(7)    Guanqun Zhan#, Fuxin Zhang#, Kailing Yang, Tao Yang, Ruixi Zhou, Chen, Wenwen, Zhang, Jingwei, Zengjun Guo,* Alscholarines A and B, two rearranged monoterpene indole alkaloids from Alstonia scholaris, Organic & Biomolecular Chemistry, 2023, 21, 8190-8196.

(8)    Fuxin Zhang, Ruixi Zhou, Tao Yang, Kailing Yang, Saisai Xin, Jingwei Zhang. Yuqiu Li, Guanqun Zhan*, Zengjun Guo*, Molecular networking accelerated discovery of biflavonoid alkaloids from Cephalotaxus sinensis, Chemistry & Biodiversity, 2023, 20, e202201197.

(9)    Fuxin Zhang, Kailing Yang, Huanhuan Liu, Tao Yang, Ruixi Zhou, Xinxin Zhang, Guanqun Zhan*, Zengjun Guo**, Structurally diverse monoterpene indole alkaloids with vasorelaxant activities from the branches of Alstonia scholaris, Phytochemistry, 2023, 209, 113610.

(10) Fuxin Zhang, Tao Yang, Kailing Yang, Ruixi Zhou, Yu Zhang, Wenwen Chen, Zhetong Liu, Guanqun Zhan*, Zengjun Guo*, Cytotoxic alkaloids from the twigs and leaves of Cephalotaxus sinensis, Organic & Biomolecular Chemistry, 2023, 21, 169-178.

(11) Guanqun Zhan, Biao Gao, Junfei Zhou, Tingting Liu, Guijuan Zheng, Zhong Jin*, Guangmin Yao*, Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities, Phytochemistry, 2023, 127, 113564.

(12) Fuxin Zhang, Huanhuan Liu, Kailing Yang, Tao Yang, Ruixi Zhou, Rongkun Miao, Guanqun Zhan*, Zengjun Guo*, New phenylpropanoids and monoterpene alkaloids with vasorelaxant activities from the branches of Alstonia scholaris, Fitoterapia, 2022, 158, 10514.

(13) Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Gang Chang, Lei Zhang, Xinxin Zhanga, Hui Zhang, Zengjun Guo*, Monoterpene indole alkaloids with acetylcholinesterase inhibitory activity from the leaves of Rauvolfia vomitoria, Bioorganic Chemistry, 2020, 102, 104136.

(14) Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Xincai Hao, Xi Zheng, Hui Zhang, Xinxin Zhang, Zengjun Guo*, Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities, Phytochemistry, 2020,177, 112450.

(15) Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Yi Hao, Yu Zhang, Yingxu Zhang, Muhammad Khurm, Xinxin Zhang, Zengjun Guo*, Peraksine derivatives with potential anti-inflammatory activities from the stems of Rauvolfia vomitoria, Fitoterapia, 2020, 146, 104704.

(16) Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Xingbin Wang, Xinxin Zhang, Zengjun Guo*, Cytotoxic Yohimbine-Type Alkaloids from the leaves of Rauvolfia vomitoria, Chemistry & Biodiversity, 2020, 17, e2000647.

(17) Guanqun Zhan, Junfei Zhou, Junjun Liu, Jinfeng Huang, Hanqi Zhang, Rong Liu, Guangmin Yao*, Acetylcholinesterase inhibitory alkaloids from the whole plants of Zephyranthes carinata, Journal of Natural Products, 2017, 80(9), 2462-2471.

(18) Guanqun Zhan, Junjun Liu, Junfei Zhou, Bin Sun, Haji Akber Aisa, Guangmin Yao*, Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors, European Journal of Medicinal Chemistry, 2017, 127, 771-780.

(19) Guanqun Zhan, Junfei Zhou, Rong Liu, Tingting Liu, Guoli Guo, Jianping Wang, Ming Xiang, Yongbo Xue, Zengwei Luo, Yonghui Zhang, Guangmin Yao*, Galanthamine, plicamine, and secoplicamine alkaloids from Zephyranthes candida and their anti-acetylcholinesterase and anti-inflammatory activities, Journal of Natural Products, 2016, 79(4), 760-766.

(20) Guanqun Zhan#, Xiaolan Qu#, Junjun Liu, Qingyi Tong, Junfei Zhou, Bin Sun, Guangmin Yao*, Zephycandidine A, the first naturally occurring imidazo[1,2-f]phenanthridine alkaloid from Zephyranthes candida, exhibits significant anti-tumor and antiacetylcholinesterase activities, Scientific Reports, 2016, 6, 33990.