1. 多模态物理能量神经调控（聚焦超声及电调控）

2. 基于神经动力学的脑机接口研究

3. 神经形态类脑边缘计算

4. 医学光谱技术

5. 医学人工智能

6. 高端医疗装备研发

2001年进入西安交通大学医学院临床医学七年制学习，2008年获硕士学位后进入陕西省人民医院骨外科（脊柱方向）工作，任住院医师、主治医师。2013年进入西安交通大学医学部攻读外科学博士，2014年至2018年赴美国约翰霍普金斯大学医学院进行神经科学联合博士培养，从事前庭神经电生理与空间感知研究、多通道人工前庭研发。2018年获得博士学位后就职于西安交通大学第二附属医院神经外科从事功能神经外科的医教研工作，方向为多模态物理能量神经调控（聚焦超声及电调控），基于神经动力学的脑机接口研究，神经形态类脑边缘计算，医学光谱技术，医学人工智能，高端医疗装备研发，带领团队研发出我国首款具有独立知识产权的多通道人工前庭原型机及工程样机（XJTU-1），治疗双侧前庭病。2021年师从徐宗本院士从事博士后研究，聚焦“边缘智能+类脑计算”神经调控新范式，致力于多模态物理能量神经调控与智能外科设备研发，神经动力学建模及医学高光谱智能解析等交叉研究。

近五年主持科研项目10项，包括国家自然科学基金面上项目、中央军委创新特区项目、中国博士后科学基金面上项目、省重点研发计划、省自然科学面上项目等，承担国家重点研发计划项目子课题1项、国家自然科学基金专项项目子任务课题1项，此外还参与国家自然科学基金面上2项、省部级科研项目3项。

近五年以一作或通讯发表AS等SCI论文17篇，以第1发明人授权发明专利12项，参编著作3部，以第1完成人获省部级创新奖3项。

代表性论著：

1 Mengke Wang, Baochen Zhang, Renhao Guo, Haiqin Wang, Di Wu, Xiaoqian Peng, Hongsong Guo, Jiawei Duan, Weina Yang#, Pengyu Ren#, Siyuan Zhang#. Restoration of autophagy-lysosomal function via transcranial focused ultrasound stimulation ameliorates β-amyloid pathology and cognitive deficits in an Alzheimer’s disease model. Ultrasonics, 2026, 165: 108075.

2 Haiqin Wang, Dapeng Li, Mengke Wang, Baochen Zhang, Zhou Jiang, Yue Wu, Jiawei Duan, Dong Huang#, Pengyu Ren#, Siyuan Zhang#. Regulation of circadian rhythm disruption in mice via transcranial low-intensity focused ultrasound stimulation targeting the suprachiasmatic nucleus. IEEE Trans Neural Syst Rehabil Eng, 2025, 33: 4468-4476.

3 Longhui Fu, Huangtao Chen, Bai Sun#, Zelin Cao, Kaikai Gao, Mengna Wang, Wentao Yan, Kun Wang, Teng Wu, Siyuan Zhang, Shouping Gong#, Pengyu Ren#. Rapid detection of brain tumor cells using memristors for biomedical applications. Materials Today Bio, 2025, 32: 101934.

4 Cong Li, Yizhu Shan, Shihao Zheng, Puchuan Tan, Yuan Bai, Engui Wang, Lingling Xu, Ruizeng Luo, Shengyu Chao, Jing Huang, Pengyu Ren#, Zhou Li#, Hongqing Feng#. Nanogenerator neuromodulation to enable locomotion rehabilitation for spinal cord injury via epidural electrical stimulation. Advanced Science, 2025, 23: e2501425.

5 Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Xiangyuan Wu, John Bosco Ruganzu, Songdi Wu, Mingtao Zhao, Lei Li, Yang Yang, Shengfeng Ji, Weina Yang#, Pengyu Ren#. TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice. Experimental Neurology, 2025, 388:115205.

6 Pengyu Ren*, Longhui Fu, Xiaojuan Gong, Li Jia, Boqiang Lyu, Mengke Wang, Siyuan Zhang, Shisheng Sun, Na Zhao, Zongben Xu, Jie Zhu#. Heterogeneities of site-specific N-glycosylation in the hippocampus of depression like behavior models induced by acute stress and chronic stress. Journal of Proteome Research, 2025, 24(3): 1039-1052.

7 Guang Yang, Siyuan Zhang#, Xiejing Li, Ting Shen, Xin Jia, Yunjie Ding, Bo Zhang, Hua Wang, Xiaopeng Li, Pengyu Ren#. A systemic study on the performance of different quantitative ultrasound imaging techniques for microwave ablation monitoring of liver. IEEE Transactions on instrumentation and measurement, 2023, 72: 1-11.

8 Dapeng Li, Fangyuan Cao, Jie Han, Mengke Wang, Chunhao Lai, Jingjing Zhang, Tianqi Xu, Ayache Bouakaz, Mingxi Wan, Pengyu Ren#, Siyuan Zhang#. The sustainable antihypertensive and target organ damage protective effect of transcranial focused ultrasound stimulation in spontaneously hypertensive rats. Journal of Hypertension, 2023, 41(5): 852-866.

9 Pengyu Ren*, Xiaorong Niu, Ruimin Zhao, Junsong Liu, Wanli Ren, Hao Dai, Jiayu Chen, Jinfeng Yan, Baiya Li, Yuan Shao, Yanxia Bai, Peng Han#. Long non-coding RNA AGAP2-AS1 promotes cell proliferation and invasion through regulating miR-193a-3p/LOXL4 axis in laryngeal squamous cell carcinoma. Cell Cycle, 2022, 21(7): 697-707.

10 Pengyu Ren*, Bowen Li, Shiyao Dong, Boqiang Lyu, Jianqiang Qu, Shouping Gong, Qing Zhang, Peng Han#. The real identity and sensory overlap mechanism of special vestibular afferent neurons that sense both rotation and linear force. Life Sciences, 2020, 259: 118144.

获奖情况：