1. 肠道菌群及其代谢产物对肝脏肿瘤（原发、转移）免疫微环境的影响

2.肝癌侵袭转移机制

医学博士，肝胆外科博士后，主任医师，博士研究生导师，西安交通大学第二附属医院普通外科副主任。

主要从事消化道疾病诊的临床、教学和科研工作，在肝胆胰脾、胃结肠等疾病的外科治疗领域有丰富的临床经验，尤其擅长肝胆胰良恶性肿瘤、胆道结石、胆管扩张症、胰腺炎、门脉高压等疾病的微创手术和综合治疗，能够熟练开展腹腔镜下肝叶及肝段切除术、胰十二指肠切除术、胆囊癌根治术、胆管癌根治术、脾切除术、胃结肠癌根治术等复杂手术。承担国家级、省级科研项目6项，发表学术论文50余篇，指导研究生10名。

担任中国医师协会肝癌专业委员会委员，中国抗癌协会癌性肠梗阻中国协作组常委，中国医师协会结直肠MDT专业委员会委员，陕西省医学会外科分会副主任委员，陕西省老年病学会肝胆胰肿瘤多学科诊疗专业委员会主任委员。

1.国家自然科学基金面上项目：PM₂.₅通过肠-肝轴诱导肝癌侵袭转移的机制研究（42477457），2025.01—2028.12，主持。

2.陕西省科技厅, 重点研发计划, 2023-YBSF-549, PM2.5对肝细胞肝癌表观遗传表达和免疫微环境影响机制的研究, 2023.01—2024.12，主持。

3.陕西省科技厅, 陕西省重点研发计划, 2020SF-058, CD80单抗及CCL22通过抑制Tregs趋化及功能对肝癌CTCs的杀伤作用, 2020.01— 2021.12，主持。

 以第一或通讯作者发表的SCI论文：

1.  Yifan Ren, Yuxuan Lu, Qing Cui, Hao Shang, Meng Fan, Yun Sun, Xiali Shi, Rongqian Wu, Hongwei Lu*. Milk fat globule—EGF factor 8/ATP‐binding cassette subfamily E member 1 axis maintains mitophagy flux homeostasis to suppress ferroptosis in acute pancreatitis. Clinical & Translational Med. 2026;16(2):e70619.

2. Rong Li, Shunle Li, Lin Shen, Junhui Li, Di Zhang, Jinmin Yu, Lanxuan Huang, Na Liu, Hongwei Lu*, Meng Xu. M6A-modified BFSP1 induces aerobic glycolysis to promote liver cancer growth and metastasis through upregulating tropomodulin 4. Mol Biomed. 2025;6(1):17.

3. Xuanbo Da, Quanyu Guo, Yuxuan Lu, Jingjing Huang, Jianto Mo, Le Lu, Meng Fan, Xiangju Zhao, Tianzi Guo, Zilin Qi, Hao Shang, Hongwei Lu*. Bile metabolite palmitic acid augments the migration of gallbladder cancer cells through the ROS/NF-кB signaling pathway. Sci Rep. 2025;16(1):1262.

4. Hao Shang, Le Lu, Meng Fan, Yuxuan Lu, Xiali Shi, Hongwei Lu*. Exosomal circHIF1A derived from hypoxic-induced carcinoma-associated fibroblasts promotes hepatocellular carcinoma cell malignant phenotypes and immune escape. International Immunopharmacology. 2024;138:112282.

5. Rong Li, Shunle Li, Lin Shen, Junhui Li, Di Zhang, Jinmin Yu, Lanxuan Huang, Na Liu, Hongwei Lu*, Meng Xu. SNHG1, interacting with SND1, contributes to sorafenib resistance of liver cancer cells by increasing m6A‐mediated SLC7A11 expression and promoting aerobic glycolysis. Environ Toxicol. 2024;39(3):1269-1282.

6. Meng Fan, Le Lu, Hao Shang, Yuxuan Lu, Yi Yang, Xiuyan Wang, Hongwei Lu*. Establishment and verification of a prognostic model based on coagulation and fibrinolysis-related genes in hepatocellular carcinoma. Aging (milano). Published online April 1, 2024.

7. Xuanbo Da, Jiantao Mo, Qiaoxin Li, Bangping Cao, Jingjing Huang, Yuxuan Lu, Le Lu, Meng Fan, Hongwei Lu*. Targeted co-delivery of PD-L1 monoclonal antibody and sorafenib to circulating tumor cells via platelet-functionalized nanocarriers. Biochemical and Biophysical Research Communications. 2023;671:335-342.

8. Le Lu, Jingjing Huang, Jiantao Mo, Xuanbo Da, Qiaoxin Li, Meng Fan, Hongwei Lu*. Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis. Cell Mol Biol Lett. 2022;27(1):17.

9. Le Lu, Ziyun Zhuang, Meng Fan, Bingli Liu, Yi Yang, Jingjing Huang, Xuanbo Da, Jiantao Mo, Qiaoxin Li, Hongwei Lu*. Green formulation of ag nanoparticles by hibiscus rosa-sinensis: Introducing a navel chemotherapeutic drug for the treatment of liver cancer. Arabian J Chem. 2022;15(2):103602.

10. Ya-Fei Zhang, Hao Shang, Xianling Zeng, Hong Ji, Yiming Li, Hongwei Lu*. Postoperative adjuvant chemo (embolization) therapy for hepatocellular carcinoma with portal vein tumor thrombosis. OTT. 2018;Volume 11:5407-5417.

11. Yafei Zhang, Yiming Li, Hong Ji, Xin Zhao, Hongwei Lu*. Transarterial Y90 radioembolization versus chemoembolization for patients with hepatocellular carcinoma: A meta-analysis. BST. 2015;9(5):289-298.

12. Hong Ji, Hongwei Lu*, Yiming Li, Le Lu, Jinlong Wang, Ya-Fei Zhang, Hao Shang. Twist promotes invasion and cisplatin resistance in pancreatic cancer cells through growth differentiation factor 15. Molecular Medicine Reports. 2015;12(3):3841-3848.

13. Hongwei Lu, Jiahong Dong*, Chonghui Li, Qiang Yu, Wei Tang. The defects of cholangiocyte primary cilia in patients with graft cholangiopathies. Clinical Transplantation. 2014;28(10):1202-1208.

14. Hongwei Lu, Jiahong Dong*, Yafei Zhang, Chonghui Li, Qiang Yu, Wei Tang. Pathological changes in primary cilia: A novel mechanism of graft cholangiopathy caused by prolonged cold preservation in a rat model of orthotopic liver transplantation. BST. 2014;8(4):206-211.

15. Hongwei Lu, Yongbing Chen, Yiming Li*, Jiahong Dong, Huining Yang. Role of hepatic arterial ischaemia in biliary fibrosis following liver transplantation. Chin Med J (Engl). 2010;123(7):907-911.