（1）脓毒症的发病机制及防治

（2）慢性疼痛的发病机制及转化

张占琴，女，39岁。2016年毕业于浙江大学麻醉学专业，获得博士学位。2017年3月至今就职于西交大一附院，现为麻醉手术部副研究员/主治医师、博士/硕士生导师。

1. 国家自然科学基金面上项目，基于表面增强空间拉曼技术的脓毒症脑病早期诊断新方法研究（82272247），52万，在研

2. 国家自然科学基金青年项目，TRPM2调控小胶质细胞LAPosomes成熟参与脓毒症脑病的机制研究（81801958），21万，结题

3. 陕西省自然科学基金青年项目，小胶质细胞TRPM2通道介导脓毒症脑病的作用及机制研究（81801958），3万，结题

4. 中央高校基本科研业务费，脂联素及脂联素受体对脓毒症脑病的保护作用及机制研究（XZY012019100），15万，结题

5. 西安交通大学第一附属医院院级课题，基于拉曼光谱技术的脓毒症早期诊断和预后预测系统构建，5万，在研

(1) Xiao Q#, Zhang Z#, Ji S, Li M, Zhang B, Xu Q, Xiao C, Guan H, Ma L, Mei X. Association between oxidative balance score and thyroid function and all-cause mortality in euthyroid adults. Sci Rep. 2025 Feb 25;15(1):6817.

 (2) Han X#, Wang S#, Cai R, Chen Q, Li J, Zhong L, Ji S, Mei X, Wu R, Yan Y*, Lv Y*, Zhang Z*. The combined use of serum Raman spectroscopy and D dimer testing for the early diagnosis of acute aortic dissection. Heliyon. 2024;10(12):e32474.

(3) Zhang Z, Hu J. DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition. J Transl Med. 2024;22(1):617.

(4) Chen Q, Shi T, Du D, Wang B, Zhao S, Gao Y, Wang S, Zhang Z. Non-destructive diagnostic testing of cardiac myxoma by serum confocal Raman microspectroscopy combined

with multivariate analysis.Anal Methods. 2023;15(21):2578-2587.封面文章

(5) Zhang Z, Ji S, Yang L, Mei X. Triptolide Alleviates Neuropathic Pain by Inhibiting the Activation of Microglial Toll-Like Receptor 3. J Integr Neurosci. 2022;21(6):150.

(6) Cheng J, Zhang M, Cheng S, Li F, Zhang B, Sun X, Hu H, Chen L, Zhao Z, Hu H, Zhang Z. Low-dose alcohol ameliorated high fat diet-induced anxiety-related behavior via enhancing adiponectin expression and activating the Nrf2 pathway. Food Funct. 2021;12(1):241-251.

(7) Zhang Z, Zhu H, Hu J. CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129. Cell Death Dis. 2021;12(2):219.

(8) Zhang Z, Yan C, Miao J, Pu K, Ma H, Wang Q.Muscle-Derived Mitochondrial Transplantation Reduces Inflammation, Enhances Bacterial Clearance, and Improves Survival in Sepsis. Shock. 2021;56(1):108-118.

(9) Wu M, Pu K, Jiang T, Zhai Q, Ma Z, Ma H, Xu F, Zhang Z, Wang Q. Early label-free analysis of mitochondrial redox states by Raman spectroscopy predicts septic outcomes. J Adv Res. 2020;28:209-219.

(10) Yan C, Ma Z, Ma H, Li Q, Zhai Q, Jiang T, Zhang Z, Wang Q.Mitochondrial Transplantation Attenuates Brain Dysfunction in Sepsis by Driving Microglial M2 Polarization. Mol Neurobiol. 2020;57(9):3875-3890.

(11) Zhang Z, Ma Z, Yan C, Pu K, Wu M, Bai J, Li Y, Wang Q. Muscle-derived autologous mitochondrial transplantation: A novel strategy for treating cerebral ischemic injury. Behav Brain Res.2019;356:322-331.

(12) Zhang Z, Lei Y, Yan C, Mei X, Jiang T, Ma Z, Wang Q. Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release. Inflammation. 2019;42(3):1082-1092.

(13) Zhang Z, Cui P, Zhang K, Chen Q, Fang X. Transient Receptor Potential Melastatin 2 Regulates Phagosome Maturation and Is Required for Bacterial Clearance in Escherichia coli Sepsis.  Anesthesiology. 2017;126(1):128-139.

(14) Liu J, Chu J, Xu J, Zhang Z, Wang S.In vivo Raman spectroscopy for non-invasive transcutaneous glucose monitoring on animal models and human subjects. Spectrochim Acta A Mol Biomol Spectrosc. 2024;329:125584.

(15) Chen J, Li Q, Zhang Z, Bratchenko IA, Su H, Wang S. A Femtosecond Fiber Laser-Based Compact Label-Free Multimodality Nonlinear Optical Microscopy and Its Ex Vivo Bioimaging. Microsc Res Tech. 2024 Dec 13.

(16) Chen N, Ji S, Liu J, Wang L, Chen F, Zhu Y, Li J, Chen M, Chen L, Wang M, He R, Mei X, Zhang Z, Jin S, Zheng J, Jiang Y. Olanzapine for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a randomized controlled trial. Ther Adv Drug Saf. 2024;15:20420986241244593.

(17) Yan B, Gao Y, Zhang Z, Shi T, Chen Q. Nocturnal oxygen saturation is associated with all-cause mortality: a community-based study.  J Clin Sleep Med. 2024;20(2):229-235.

(18) Zhou RS, Xue XH, Bi Y, Yang TT, Zhang ZQ, Zhu HY, Wang Q. Sevoflurane Activates PI3K/AKT Signaling Pathway by Upregulating GDF11 Expression to Attenuate Ischemia/Reperfusion Injury in Cardiomyocytes. Discov Med. 2024;36(189):2071-2078.

(19) Zhang Y, Lu Y, Zhang Z, Liang Z, Xiao Q, Shao K, Wang Y, Zhang J, Wang S. A rapid multispectral endoscopic imaging system for in vivo assessment of the morphological and physiological characteristics of mouse intestines. Anal Methods. 2023;15(41):5518-5525.

(20) Chen Q, Wu Y, Gao Y, Zhang Z, Shi T, Yan B. Effect of visceral adipose tissue mass on coronary artery disease and heart failure: A Mendelian randomization study. Int J Obes (Lond). 2022;46(12):2102-2106.

(21) Zhang B, Zhang Z, Gao B, Zhang F, Tian L, Zeng H, Wang S. Raman microspectroscopy based TNM staging and grading of breast cancer.  Spectrochim Acta A Mol Biomol Spectrosc. 2023;285:121937.

(22) Wang X, Gao H, Zhang Z, Deng C, Yan Y, Shi T. Effect of the COVID-19 pandemic on complications and mortality of patients with cardiac surgery.  J Cardiothorac Surg. 2021;16(1):361.

(23) Jiang T, Wu M, Zhang Z, Yan C, Ma Z, He S, Yuan W, Pu K, Wang Q. Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats. Mol Med. 2019;25(1):22.

(24) Hu J, Meng Y, Zhang Z, Yan Q, Jiang X, Lv Z, Hu L. MARCH5 RNA promotes autophagy, migration, and invasion of ovarian cancer cells.Autophagy. 2017;13(2):333-344.