长期致力于新型智能药物递送系统的设计、合成及其在肿瘤精准治疗和生物医学工程领域中的应用与临床转化研究。重点关注磁场、超声波、pH、氧化还原等刺激响应递送平台、载药微球介入递药体系、智能仿生递药体系等。研究内容主要包括：

（1）肿瘤微环境响应性药物递送系统的设计及其在肿瘤诊疗及重塑免疫微环境中的应用研究；

（2）载药微球的设计、合成及其在肝癌介入栓塞中的应用及临床转化研究；

（3）医工交叉智能仿生磁控介入体系的研发与医学应用。

教育及工作经历：

2023.09-至今，西安交通大学“青年拔尖人才计划”入选者，特聘研究员、博士生导师

2019.09-2023.07，厦门大学·公共卫生学院·生物化学与分子生物学，博士（导师：刘刚教授）

2016.09-2019.07，西南大学·材料与能源学院·纳米生物医学，硕士（导师：许志刚教授）

2012.09-2016.07，西北农林科技大学·植物保护学院·制药工程，学士

近年来，已发表学术论文30余篇。其中以第一/通讯作者（含共同）身份在Advanced Materials、ACS Nano、Advanced Functional Materials、Advance Science、Nano-Micro Letters、Nano Today等权威期刊发表SCI论文15篇，总影响因子超过200，其中 Top论文（IF>10）13篇。另取得国家发明专利3项，参编英文论著1篇，担任《Nano TransMed》期刊青年编委，主持科研经费150余万元。

代表性论文（#共同一作，*通讯作者）：

1. Shuang Bai#, Hu Chen#, Shiying Fu#, Chao Liu, Xing Gao, Shuo Li, Yulun Chen, Yulu Lan, Yutian Xia, Qixuan Dai, Pan He, Yang Zhang, Qingliang Zhao, Jingsong Mao*, Zhixiang Lu*, Gang Liu*, Bioinspired Tumor Calcification-Guided Early Diagnosis and Eradication of Hepatocellular Carcinoma. Advanced Materials, 2024, 2310818. (5-Year IF: 30.2)

2. Shuang Bai#, Zhixiang Lu#, Yonghe Jiang, Xiaoxiao Shi, Dazhuang Xu, Yesi Shi, Gan Lin, Chao Liu, Yang Zhang*, Gang Liu*, Nanotransferrin-Based Programmable Catalysis Mediates Three-Pronged Induction of Oxidative Stress to Enhance Cancer Immunotherapy. ACS Nano, 2022, 16, 997-1028. (5-Year IF: 16.2)

3. Shuang Bai#, Shuqin Xu#, Yulu Lan#, Zhixiang Lu, Long Liu, Weilun Son, Rongqian Wu, Feng Ma, Hu Chen*, Yun Zeng*, Yi Lv*, Gang Liu*, Three-Pronged Induction of Tumor Calcification Synergistic Calcium Immunotherapy Enables Diagnosis and Cure of Cancer. Advanced Functional Materials, 2024. (5-Year IF: 19.6)

4. Shuang Bai#, Yulu Lan#, Shiying Fu, Hongwei Cheng, Zhixiang Lu*, Gang Liu*, Connecting Calcium-Based Nanomaterials and Cancer: from Diagnosis to Therapy. Nano-Micro Letters, 2022,14, 145. (5-Year IF: 26)

5. Shuang Bai, Die Jia, Xianbin Ma, Mengyun Liang, Peng Xue, Yuejun Kang, Zhigang Xu*, Cylindrical Polymer Brushes-Anisotropic Unimolecular Micelle Drug Delivery System for Enhancing the Effectiveness of Chemotherapy. Bioactive Materials, 2021, 6, 2894-2904. (ESI highly cited paper) (5-Year IF: 18.2)

6. Shuang Bai#, Yang Zhang#, Dengfeng Li, Xiaoxiao Shi, Gang Liu*, Gain an Advantage from Both Sides: Smart Size-Shrinkable Drug Delivery Nanosystems for High Accumulation and Deep Penetration. Nano Today, 2020, 36, 101038. (5-Year IF: 14.6)

7. Shuang Bai#, Leilei Yang#, Yajun Wang, Tian Zhang, Lvqin Fu, Shaochen Yang, Shucheng Wan, Shuo Wang, Die Jia, Baosheng Li, Peng Xue, Yuejun Kang, Zhijun Sun* and Zhigang Xu*. Prodrug-Based Versatile Nanomedicine for Enhancing Cancer Immunotherapy by Increasing Immunogenic Cell Death. Small, 2020, 16, 2000214. (5-Year IF: 13.5)

8. Shuang Bai, Meili Hou, Xiaoxiao Shi, Jiuncun Chen, Xiaoqian Ma, Yong-E Gao, Yajun Wang, Peng Xue, Yuejun Kang*, Zhigang Xu*, Reduction-Active Polymeric Prodrug Micelles Based on α-Cyclodextrin Polyrotaxanes for Triggered Drug Release and Enhanced Cancer Therapy. Carbohydrate Polymers, 2018, 193, 153-162. (5-Year IF: 10.2)

9. Shuang Bai, Yong-E Gao, Xiaoqian Ma, Xiaoxiao Shi, Meili Hou, Peng Xue*, Yuejun Kang*, Zhigang Xu*, Reduction Stimuli-Responsive Unimolecular Polymeric Prodrug Based on Amphiphilic Dextran-Framework for Antitumor Drug Delivery. Carbohydrate Polymers, 2018, 182, 235-244. (5-Year IF: 10.2)

10. Shuang Bai, Xiaoqian Ma, Xiaoxiao Shi, Jinjun Shao, Tian Zhang, Yilong Cheng, Peng Xue, Yuejun Kang and Zhigang Xu*, Smart Unimolecular Micelles-Based Polyprodrug with Dual Redox Stimuli-Response for Tumor Microenvironment: Enhanced in Vivo Delivery Efficiency and Tumor Penetration. ACS Applied Materials & Interfaces, 2019, 11, 32, 36130-36140. (5-Year IF: 8.7)

11. Shuang Bai, Xiaoli Zhang, Xiaoqian Ma, Jiuncun Chen, Qiubing Chen, Xiaoxiao Shi, Meili Hou, Peng Xue, Yuejun Kang*, Zhigang Xu*, Acid-Active Supramolecular Anticancer Nanoparticles Based on Cyclodextrin Polyrotaxanes Damaging Both Mitochondria and Nuclei of Tumor Cells. Biomaterials Science, 2018, 6, 3126-3138. (Front cover) (5-Year IF: 6.2)

12. Mengjie Ye, Junfeng Hu, Linlin Han, Hengbo Zhang, Peng Xue, Yuejun Kang, Shuang Bai*, and Zhigang Xu*, Neighboring Effect-initiated Supramolecular Nanocomplex with Sequential Infiltration as Irreversible Apoptosis Inducer for Synergetic Chemo-immunotherapy, Advanced Science, 2024, 2402809. (IF 14.3, Co-corresponding author) (5-Year IF: 16.3)

13. Zhixiang Lu#, Shuang Bai#, Yonghe Jiang, Shuaiying Wu, Dazhuang Xu, Xuan Liu*, Gang Liu *, Porphyrin-Based Covalent Organic Framework for Imaging-Guided Cancer Combinatorial Immuno-Sonodynamic Therapy. Advanced Functional Materials, 2022, 2207749. (5-Year IF: 19.6)

14. Zhixiang Lu#, Shuang Bai#, Yonghe Jiang, Shuaiying Wu, Dazhuang Xu, Jianzhong Zhang, Hongrui Zhang, Yesi Shi*, Gang Liu*, Amplifying Dendritic Cell Activation by Bioinspired Nanometal Organic Frameworks for Synergistic Sonoimmunotherapy. Small, 2022, 2203952. (5-Year IF: 13.5)

15. Zhixiang Lu#, Shuang Bai#, Yesi Shi, Chengchao Chu*, Gang Liu*, Artificial Nanocage-Based 3D Framework Platforms: From Construction Design to Biomedical Applications. Chemical Engineering Journal, 2021, 426, 131891. (5-Year IF: 13.2)

16. Shuaiying Wu#, Chao Liu#, Shuang Bai#, Zhixiang Lu*, Gang Liu*, Broadening the Horizons of RNA Delivery Strategies in Cancer Therapy. Bioengineering, 2022, 9, 576. (IF: 3.8)

Book Chapter：

1. Shuang Bai, Xiaoqian Ma, Tian Zhang, Yong-E Gao, Yajun Wang, Yuan Gao, Zhigang Xu*, Chapter 12: Polymeric Micelles as Delivery Systems, Nanoengineered Biomaterials for Advanced Drug Delivery, Publisher: Elsevier Ltd. 2020, 261-278. 

欢迎博士后加入研究团队！

欢迎硕士/博士研究生报考！