张伊 |
心血管病理生理学:
1.鞘磷脂信号影响心肌免疫应答、心脏组织纤维化的分子机制;
2.内皮通透性及冠状动脉斑块形成的机制;
3.心肌钙离子信号调控在心律失常中的作用机制。
2017.11~至今,西安交通大学医学部, 基础医学院, 生理学与病理生理学系,副教授
2012.11~2017.10, 美国康奈尔大学威尔医学院病理与实验药物学系,血管生物学中心,博士后
2007.09~2012.07,北京大学分子医学研究所,生物物理 博士(导师:中国科学院院士 程和平教授)
2003.09~2007.07,中国农业大学动物科学与技术学院,学士
1.2019.01~2022.12,内皮细胞Nogo-B在高血压诱发冠状动脉粥样硬化过程中的作用与机制,国家自然科学基金面上项目,60.0万,主持
2.2019.01-2020.12,冠状动脉内皮细胞中S1P-S1PR1在心脏重构中的作用与机制,陕西省自然科学基金青年项目,3.0万,主持
3.2019.09-2024.09,西安交通大学医学部“攀登人才”支持计划,20.0万,主持
4.2019.01-2021.12,2019T120919,Nogo-A调控线粒体钙转运及其对心肌肥大的影响研究,第12批中国博士后科学基金特别资助项目,18.0万,主持
5.2019.01-2021.12,Nogo-B调控鞘磷脂代谢在高血压诱发冠状动脉粥样硬化中的作用,陕西省博士后基金项目,8.0万,主持
6.2018.01-2020.12,2018M631174,S1PR1在压力超负荷所致心力衰竭中的作用与机制,第63批中国博士后科学基金面上项目一等资助,8.0万,主持
7.2018.01-2020.12,S1PR1在RyR2磷酸化及心衰中的作用与机制研究,西安交通大学基本科研业务费,15.0万,主持
8.2018.01-2020.12,冠状动脉内皮细胞S1PR1在压力超负荷所致心力衰竭中的作用与机制,西安交通大学新教师科研支持计划,15.0万,主持
1.Ying Qi#, Jing-Jing Li#, Xiao-Hui Di#, Yu Zhang#, Jie-Long Chen, Zi-Xuan Wu, Zi-Yue Man, Ru-Yue Bai, Fujian Lu, Jie Tong, Xue-Liang Liu, Xiu-Ling Deng, Jianbao Zhang, Xing Zhang, Yi Zhang*, and Wenjun Xie*. Excess sarcoplasmic reticulum-mitochondria calcium transport induced by Sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy. Biochimica et Biophysica Acta-Molecular Cell Research. 2021 Apr. 1868(5):118970. (期刊论文)(IF:4.739)
2.Yi Zhang#, Ying Qi#, Jing-Jing Li#, Xiao-Hang Gao, Yu Zhang, Xia Sun, Wen-Jin He, Jie Tong, Jianbao Zhang, Xiu-Ling Deng, Xiao-Jun Du, Wenjun Xie*. Stretch-induced sarcoplasmic reticulum calcium leak promotes atrial fibrillation in pressure-overloaded hearts. Cardiovascular Research, 2021 Mar 21;117(4):1091-1102. doi: 10.1093/cvr/cvaa163. (期刊论文) (IF:10.787)
3.Yi Zhang#, Meng-Chen Hou#, Jing-Jing Li, Ying Qi, Yu Zhang, Gang She, Yu-Jie Ren, Wei Wu, Zheng-Da Pang, Wenjun Xie, Xiu-Ling Deng*, Xiao-Jun Du*. Cardiac beta-adrenergic receptor activation mediates distinct and cell type-dependent changes in the expression and distribution of connexin 43,Journal of Cellular and Molecular Medicine, 2020, 24(15): 8505-8517. (期刊论文) (IF:5.310)
4.Yi Zhang, Yan Huang, Anna Cantalupo, Paula S. Azevedo, Mauro Siragusa, Jacek Bielawski, Frank J. Giordano, and Annarita Di Lorenzo*. Endothelial Nogo-B regulates sphingolipid biosynthesis to promote the transition from hypertrophy to heart failure during chronic pressure overload. JCI Insight. 2016 Apr 21; 1(5): e85484.(期刊论文) (IF:8.315)
5.Anna Cantalupo#, Yi Zhang#, Milankumar Kothiya, Sylvain Galvani, Hideru Obinata, Mariarosaria Bucci, Frank J. Giordano, Xian-Cheng Jiang, Timothy Hla, and Annarita Di Lorenzo*. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nature Medicine. 2015, 21(9): 1028-1037. (期刊论文) (IF=30.641)
6.Sasset, Linda#; Yi Zhang #; Teresa M. Dunn, and Annarita Di Lorenzo*. Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. Trends Endocrinol Metab. 2016 Nov; 27(11):807-819. Review
7.Xianhua Wang*#, Wenjun Xie#, Yi Zhang#, Peihui Lin, Liang Han, Peidong Han, Yanru Wang, Zheng Chen, Guangju Ji, Ming Zheng, Noah Weisleder, Rui-Ping Xiao, Hiroshi Takeshima, Jianjie Ma*, and Heping Cheng. Cardioprotection of ischemia-reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res. 2010 Jul 9; 107(1):76-83. (IF=15.862)