研究方向：心血管病理生理学

1.鞘磷脂信号在心肌、血管内皮中介导心脏重构和纤维化的病理机制；

2.内质网-线粒体互作调节钙稳态-氧化应激信号在心律失常的病理机制。

招生方向：

1.病理生理学：先天、遗传性疾病及心律失常发病机制及防治研究

2.生理学： 心脑血管疾病与代谢性疾病的发病机制及防治研究

2024.01~至今，西安交通大学医学部, 基础医学院, 生理学与病理生理学系，教授，博导

2017.11~2023.12，西安交通大学基础医学院生理学与病理生理学系，副教授，博导

2012.11~2017.10， 美国康奈尔大学威尔医学院病理与实验药物学系，博士后

2007.09~2012.07，北京大学分子医学研究所，生物物理学，博士（导师：程和平院士）

2003.09~2007.07，中国农业大学，学士

主持国家自然科学基金面上项目2项、航天医学实验项目1项、中国博士后基金项目2项、陕西省自科项目2项。

目前共发表研究性论文30余篇，其中通讯/第一作者研究性论文14篇（6篇IF>10），2019年入选西安交通大学医学部“攀登人才”计划。现任中国病理生理学会理事，病理生理学会心血管专业委员会青年委员。

代表性SCI论文

1.     Xin-Yi Zhao, Rui Xu, Jing-Jing Li, Yu-Peng Chen, Pei-Ning Liu, Jia-Hui Yao, Xin-Pei Wang, Yi-Wei Hu, Jing Lou, Fan Xu, Gang She, Zheng-Da Pang, Ning Huang, Zhe Song, Xiu-Ling Deng, Xiao-Jun Du, Xing Zhang*, Yi Zhang*(第一通讯作者), Wenjun Xie*.S1PR1-MYPT1 Maintains Coronary Endothelial Barrier in Pressure-Overloaded Hearts. Hypertension. 2025 (In press). (IF: 8.2)

2.   Gang She, Xia-Xia Hai, Li-Ye Jia, Yong-Jian Zhang, Yu-Jie Ren, Zheng-Da Pang, Lin-Hong Wu, Meng-Zhuan Han, Yu Zhang, Jing-Jing Li, Ru-Yue Bai, Bao-Chang Lai, Yi-Yi Yang, Junichi Sadoshima, Xiao-Jun Du* , Xiu-Ling Deng*, Yi Zhang*(共同通讯作者).Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1. Redox Biology. 82 (2025) 103597 (IF: 11.9)

3.     Yu Zhang, Jing-Jing Li, Rui Xu, Xin-Pei Wang, Xin-Yi Zhao, Yuan Fang, Yu-Peng Chen, Shan Ma, Xiao-Hui Di, Wei Wu, Gang She, Zheng-Da Pang, Yi-Dong Wang, Xing Zhang, Wenjun Xie, Xiu-Ling Deng, Xiao-Jun Du, Yi Zhang*. Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts. Redox Biology. 2023 Dec; 68:102944. (IF=11.4)

4.     Jing-Jing Li#, Xin-Yi Zhao#, Yan Wang#, Rui Xu, Xiao-Hui Di, Yu Zhang, Hongyan Yang, Meng-Zhuan Han, Ru-Yue Bai, Lin Xie, Zheng-Da Pang, Xing Zhang, Jianbao Zhang, Xiao-Jun Du, Xiu-Ling Deng*, Yi Zhang* (corresponding author), Wenjun Xie*. Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis. Arterioscler Thromb Vasc Biol. 2023 May; 43(5):726-738. (IF=10.514，Commented by Prof. Faraci in Arterioscler Thromb Vasc Biol. 2023 Jun;43(6):852-854)

5.     Linda Sasset#, Onorina Laura Manzo#, Yi Zhang# (co-first author), Alice Marino, Luisa Rubinelli, Maria Antonietta Riemma, Madhavi Latha S Chalasani, Dragos C Dasoveanu, Fiorentina Roviezzo, Stanislovas S Jankauskas, Gaetano Santulli, Maria Rosaria Bucci, Theresa T Lu, Annarita Di Lonrenzo*. Nogo-A reduces ceramide de novo biosunthesis to protect from geart failure. Cardiovasc Res. 2023 Mar 31; 119(2):506-519. (IF=14.239)

6.     Ying Qi#, Jing-Jing Li#, Xiao-Hui Di#, Yu Zhang#, Jie-Long Chen, Zi-Xuan Wu, Zi-Yue Man, Ru-Yue Bai, Fujian Lu, Jie Tong, Xue-Liang Liu, Xiu-Ling Deng, Jianbao Zhang, Xing Zhang, Yi Zhang* (corresponding author), and Wenjun Xie*. Excess sarcoplasmic reticulum-mitochondria calcium transport induced by Sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy. Biochim Biophys Acta Mol Cell Res. 2021 Apr; 1868(5):118970. (IF=5.011)

7.     Yi Zhang#, Ying Qi#, Jing-Jing Li#, Xiao-Hang Gao, Yu Zhang, Xia Sun, Wen-Jin He, Jie Tong, Jianbao Zhang, Xiu-Ling Deng, Xiao-Jun Du, Wenjun Xie*. Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts. Cardiovasc Res. 2021 Mar 21; 117(4):1091-1102.  (IF=14.239)

8.     Yi Zhang#, Meng-Chen Hou#, Jing-Jing Li, Ying Qi, Yu Zhang, Gang She, Yu-Jie Ren, Wei Wu, Zheng-Da Pang, Wenjun Xie, Xiu-Ling Deng*, Xiao-Jun Du*. Cardiac β-adrenoceptor activation mediates diverse and cell type-dependent changes in the expression and distribution of connexin 43. J Cell Mol Med. 2020 Aug; 24(15):8505-8517. (IF=5.310)

9.     Linda Sasset#, Yi Zhang# (co-first author), Teresa M. Dunn, and Annarita Di Lorenzo*. Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. Trends Endocrinol Metab. 2016 Nov; 27(11):807-819. (IF=10.983)

10. Yi Zhang, Yan Huang, Anna Cantalupo, Paula S. Azevedo, Mauro Siragusa, Jacek Bielawski, Frank J. Giordano, and Annarita Di Lorenzo*. Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload. JCI Insight. 2016 Apr 21; 1(5): e85484. (IF=6.014)

11.         Anna Cantalupo#, Yi Zhang# (co-first author), Milankumar Kothiya, Sylvain Galvani, Hideru Obinata, Mariarosaria Bucci, Frank J. Giordano, Xian-Cheng Jiang, Timothy Hla, and Annarita Di Lorenzo*. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat Med. 2015 Sep; 21(9):1028-37. (IF=30.641)

12.         Xianhua Wang*#, Wenjun Xie#, Yi Zhang# (co-first author), Peihui Lin, Liang Han, Peidong Han, Yanru Wang, Zheng Chen, Guangju Ji, Ming Zheng, Noah Weisleder, Rui-Ping Xiao, Hiroshi Takeshima, Jianjie Ma*, and Heping Cheng. Cardioprotection of ischemia-reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res. 2010 Jul 9; 107(1):76-83. (IF=15.862)