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侯玉柱 |
主要从事肿瘤免疫学研究，从分子、细胞及机体整体水平上，研究肿瘤发生、发展及治疗过程中的免疫学机制，包括：（1）研究肿瘤发生、发展过程中的免疫监视与免疫逃逸；（2）研究放疗与免疫治疗过程中肿瘤免疫微环境以及系统性免疫反应。
2011年9月－2014年12月：博士后，免疫学，中科院动物所；
2015年1月－2017年12月：博士后，肿瘤免疫学，美国芝加哥大学；
2018年1月－2019年12月：讲师，肿瘤免疫学，美国芝加哥大学；
2020年1月－至今：教授、博士生导师，西安交通大学。
主持国家自然基金面上项目、陕西省杰出青年项目、西安交大学青年拔尖人才项目、基本科研业务费等项目。
主要研究成果以第一或通讯作者发表在Immunity、Science Translational Medicine、Science Immunology、Journal of Hematology and Oncology, Clinical Cancer Research, Cancer Research 等著名医学学术期刊，合计公开发表SCI论文30余篇，被引用2000余次。
代表性论文：
Yufei Cao, Moujiang Zheng, Jiahong Shi, Jiale Si, Guopu Huang, Yuanyuan Ji, Yuzhu Hou*, Zhishen Ge*. X-ray-Triggered Activation of Polyprodrugs for Synergistic Radiochemotherapy. Biomacromolecules, 2025 Jan 13;26(1):579-590. doi: 10.1021/acs.biomac.4c01373 (IF: 5.5)
Jun-Rui Feng, Xue Li, Cong Han, Yue Chang, Yu Fu, Gong-Chang Feng, Yutiantian Lei, Hai-Yun Li, Patrick Ming-Kuen Tang, Shang-Rong Ji, Yuzhu Hou*, Yi Wu*. C-Reactive Protein Induces Immunosuppression by Activating FcγR2B in Pulmonary Macrophages to Promote Lung Metastasis. Cancer Research, 2024 Dec 16;84(24):4184-4198. doi: 10.1158/0008-5472.CAN-24-0253 (IF: 12.5)
Ke-Jia Lv, Si-Zhe Yu, Yu Wang, Shi-Rong Zhang, Wen-Yuan Li, Jia Hou, De-Li Tan, Hui Guo, Yuzhu Hou*. Cancer-associated fibroblasts promote the progression and chemoresistance of HCC by inducing IGF-1. Cellular Signalling, 2024 Dec:124:111378. doi: 10.1016/j.cellsig.2024.111378 (IF: 4.4)
Yuzhu Hou, Kaiting Yang, Liangliang Wang, Jiaai Wang, Xiaona Huang, András Piffkó, Sean Z Luo, Xinshuang Yu, Enyu Rao, Carlos Martinez, Jason Bugno, Matthias Mack, Everett E Vokes, Sean P Pitroda, Steven J Chmura, Ralph R Weichselbaum*, Hua Laura Liang*. Radiotherapy Enhances Metastasis Through Immune Suppression by inducing PD-L1 and MDSC in distal sites. Clinical Cancer Research, 2024; 30(9): 1945-1958 (IF: 11.1)
Yuanyuan Zhang, Yujie Zhang, Yonghong Li, Yuhan Fu, Yuanru Zhao, Wei Zhao, Runqing Li, Yao Xian, Kangsheng Tu, Feng Wu, Cheng Li*, Yuzhu Hou*, Mingzhen Zhang*. Harnessing Ag2S quantum dots with immune adjuvant for NIR-II fluorescence imaging-guided sonodynamic immunotherapy of colon cancer. Chemical Engineering Journal, 2023; 474. doi: 10.1016/j.cej.2023.145685 (IF: 15.1)
Liangliang Xu#, Chang Zou#, Shanshan Zhang#, Timothy Shun Man Chu, Yan Zhang, Weiwei Chen, Caining Zhao, Li Yang, Zhiyuan Xu, Shaowei Dong, Hao Yu, Bo Li, Xinyuan Guan, Yuzhu Hou*, Feng-Ming Kong*. Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors. Journal of Hematology and Oncology, 2022; 15(1):87. doi: 10.1186/s13045- 022-01307-2 (IF: 23.1)
Yuzhu Hou#*, Hua L Liang#, Xinshuang Yu, Zhida Liu, Xuezhi Cao, Enyu Rao, Xiaona Huang, Liangliang Wang, Lei Li, Jason Bugno, Yanbin Fu, Steven J Chmura, Wenjun Wu, Sean Z Luo, Wenxin Zheng, Ainhoa Arina, Jessica Jutzy, Anne R McCall, Everett E Vokes, Sean P Pitroda, Yang-Xin Fu*, Ralph R Weichselbaum*. Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity. Science Translational Medicine, 2021; 13(528):eabb0130. doi: 10.1126/scitranslmed.abb0130 (IF: 19.3)
Enyu Rao#, Yuzhu Hou#, Xiaona Huang, Liangliang Wang, Jiaai Wang, Wenxin Zheng, Hengjin Yang, Xinshuang Yu, Kaiting Yang, Jason Bugno, Xingchen Ding, Everett Vokes, Yang-Xin Fu, Ralph R Weichselbaum*, Hua L Liang*. All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages. Science Immunology, 2021; 6(60):eaba8426. doi: 10.1126/sciimmunol.aba8426 (IF: 30.6)
Yuzhu Hou, Hua Liang, Enyu Rao, Wenxin Zheng, Xiaona Huang, Liufu Deng, Yuan Zhang, Xinshuang Yu, Meng Xu, Helena Mauceri, Ainhoa Arina, Ralph R Weichselbaum*, Yang-Xin Fu*. Non-canonical NF-κB antagonizes STING sensor-mediated DNA sensing in radiotherapy. Immunity, 2018; 49(3): 490-503. (IF: 22.5)
Yuzhu Hou#, Linnan Zhu#, Hongling Tian, Haixi Sun, Lianfeng Zhang, Ruoyu Wang, Yong Zhao*. IL-23-induced macrophage polarization and its pathological roles in mice withimiquimod-induced psoriasis. Protein Cell. 2018; doi: 10.1007/s13238-018-0505-z (IF: 10.1)
Yuzhu Hou#, Haijiang Lin#, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Huifang Guo, Lianfeng Zhang, Qiang Wang, Zhanguo Li, Yong Zhao*. The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis. Journal of Immunology, 2014;193(1):130-8 (IF: 4.8)
Yuzhu Hou#, Haijiang Lin#, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Mingzhao Zhu, Bernard F Godley, Qiang Wang, Zhanguo Li, Yong Zhao*. LPS increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA1 expression. Arthritis & Rheumatism. 2013; 65(11): 2835-46. (IF: 9.5)
