软物质结构与功能；生物磁效应；反常化学计量比物质

2003.7 西安交通大学 理学学士  应用物理学

2006.5 西安交通大学 理学硕士  理论物理（斑图动力学）

2010.6 西安交通大学 理学博士  凝聚态物理（电子显微镜学）

2011-2014 美国劳伦斯伯克利国家实验室 博士后 蛋白结构与功能（电子显微镜）

2011.1–2014.1  博士后研究员 美国劳伦斯伯克利国家实验室材料科学部，纳米中心

2014.2–2015.9  项目科学家   美国劳伦斯伯克利国家实验室材料科学部，纳米中心

2015.9–今   物理学教授   西安交通大学物理学院应用物理系

1.国家自然科学基金杰出青年科学基金项目，蛋白质磁效应的物质结构基础，2025/1-2029/12，400万元，在研，主持

2.国家自然科学基金优秀青年科学基金项目，生物大分子动态结构与功能，2020/1-2022/12，120万元，已结题，主持

3. 国家自然科学基金重点项目，DNA损伤修复中的若干关键物理问题及单分子解决方案，2019/1-2023/12，310万元，已结题，骨干

4. 国家自然科学基金面上项目，初生态盘状高密度脂蛋白结构与功能关系的微观物理机理研究，2018/1-2021/12，70万元，已结题，主持

5. 国家自然科学基金应急管理项目，“第十四期理论物理专题讲学”活动，2018/1-2018/12，35万元，已结题，主持

6. 国家自然科学基金青年科学基金项目，11504287，9.6nm高密度脂蛋白结构与功能的透射电子显微镜与分子动力学模拟研究，2016/1-2018/12，24万元，已结题，主持

国家杰青、优青，西安交通大学领军学者

1. Lei Zhang#, Feng Yan#, Shengli Zhang, Dongsheng Lei, M. Arthur Charles, Giorgio Cavigiolio, Michael Oda, Ronald M. Krauss, Karl H. Weisgraber, Kerry-Anne Rye, Henry J. Pownall, Xiayang Qiu, and Gang Ren*. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein, Nature Chemical Biology 8(4): 342-349 (2012).

2. Ke Sun#, Changjian Zhao#, Yuejia Chen#, Xiaojun Zeng#, Xin Jiang#, Xianting Ding, Lu Gou, Haiyang Xie, Xinqiong Li, Xialin Zhang, Sheng Lin, Linqin Dou, Long Wei, Haofu Niu, Ming Zhang, Ruocen Tian, Erica Sawyer, Qingyue Yuan, Yuqin Huang, Piaopiao Chen, Chengjian Zhao, Cuisong Zhou, Binwu Ying, Bingyang Shi, Xiawei Wei, Ruotian Jiang, Lei Zhang*, Guangwen Lu*, and Jia Geng*, Active DNA Unwinding and Transport by a Membrane-Adapted Helicase Nanopore, Nature Communications 10: 5083 (2019).

3. Lei Zhang#, Guosheng Shi#, Bingquan Peng#, Pengfei Gao#, Liang Chen, Ni Zhong, Liuhua Mu, Han Han, Lijing Zhang, Peng Zhang, Lu Gou, Yimin Zhao,  Shanshan Liang, Jie Jiang, Zejun Zhang, Hongtao Ren,  Xiaoling Lei, Long Yan*, Chungang Duan*, Shengli Zhang*, and Haiping Fang*, Novel 2D CaCl crystals with metallicity, room-temperature ferromagnetism, heterojunction, piezoelectricity-like property, and monovalent calcium ions, National Science Review, 8(7): nwaa274 (2021).

4. Bingquan Peng,Yimin Zhao, Dexi Nie, RuobingYi, Liang Chen*, and Lei Zhang*, Selective transport properties of graphene oxide membranes for various cations observed in situ using quartz crystal microbalance, Applied Surface Science 541:148502 (2021).

5. Peng Xiao#, Wei Yan#, Lu Gou#, Ya-Ni Zhong#, Liangliang Kong#, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan-Cheng Yang, Anjie Xia, Zhenquan Hu, Qianqian Zhang, Yong-Hao He, Dao-Lai Zhang, Chao Zhang, Gui-Hua Hou, Huanxiang Liu, Lizhe Zhu, Ping Fu, Shengyong Yang, Daniel M. Rosenbaum, Jin-Peng Sun*, Yang Du*, Lei Zhang*, Xiao Yu*, and Zhenhua Shao*, Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes, Cell (封面), 184(4): 943-956 (2021).

6. Yimin Zhao#, Quan Zhang#, Yunzhang Li, Liang Chen, Ruobing Yi, Bingquan Peng, Dexi Nie, Lihao Zhang, Guosheng Shi, Shengli Zhang*, and Lei Zhang*, Graphitic-like Hexagonal Phase of Alkali Halides in Quasi-Two-Dimensional Confined Space under Ambient Conditions, ACS Nano 16: 2046−2053 (2022).

7. Peng Xiao#, Shengchao Guo#, Xin Wen#, Qing-Tao He#, Hui Lin#, Shen-Ming Huang#, Lu Gou#, Chao Zhang, Zhao Yang, Ya-Ni Zhong, Chuan-Cheng Yang, Yu Li, Zheng Gong, Xiao-Na Tao, Zhi-Shuai Yang, Yan Lu, Shao-Long Li, Jun-Yan He, Chuanxin Wang, Lei Zhang*, Liangliang Kong*, Jin-Peng Sun*, and Xiao Yu*, Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4, Nature 604: 771-778 (2022).

8. Yu Cao#, Tianyi Tan#, David M. Walba, Noel A. Clark, Goran Ungar, Chenhui Zhu, Lei Zhang*, and Feng Liu*, Understanding and Manipulating Helical Nanofilaments in Binary Systems with Achiral Dopants, Nano Letters 22(11): 4569–4575 (2022).

9. Yimin Zhao, Quan Zhang, Jianbing Ma, Ruobing Yi, Lu Gou, Dexi Nie, Xiaona Han, Lihao Zhang, Yuetian Wang, Xintong Xu, Zhe Wang, Liang Chen, Ying Lu*, Shengli Zhang*, and Lei Zhang*, Directional growth of quasi-2D Cu2O monocrystals on rGO membranes in aqueous environments, iScience 25: 105472 (2022).

10. Xuhua Li, Yujie Chen, Zhiwei Yang, Shengli Zhang, Guanghong Wei*, and Lei Zhang*, Structural insights into the co-aggregation of Aβ and tau amyloid core peptides: Revealing potential pathological heterooligomers by simulations, International Journal of Biological Macromolecules  254: 127841 (2024).

11. Na Li#, Jianbing Ma#, Hang Fu#, Zhiwei Yang#, Chunhua Xu, Haihong Li, Yimin Zhao, Yizhen Zhao, Shuyu Chen, Lu Gou, Xinghua Zhang, Shengli Zhang, Ming Li, Ximiao Hou*, Lei Zhang*, Ying Lu*, Four Parallel Pathways in T4 Ligase-Catalyzed Repair of Nicked DNA with Diverse Bending Angles, Advanced Science 11(25): 2401150 (2024).

12. Ruobing Yi#, Jie Jiang#, Yizhou Yang#*, Yueyu Zhang*, Siyan Gao, Yimin Zhao, Jiahao Hu, Xuchang Su, Xinming Xia, Bingquan Peng, Fangfang Dai, Pei Li, Zhao Guan, Haijun Yang, Fangyuan Zhu, Jiefeng Cao, Zhe Wang, Haiping Fang, Lei Zhang*, and Liang Chen*, Two-dimensional anion-rich NaCl2 crystal under ambient conditions, Nature Communications 16: 464 (2025).