内分泌药理学；心血管药理学

陈莉娜，教授，博士生导师，基础医学院党委副书记。研究方向为内分泌药理学和心血管药理学，主要从事糖尿病等代谢性疾病的发病机制及药物防治研究。2009-2010年在美国内布拉斯加大学医学中心药理学与实验神经科学系做访问学者；2015年8-11月赴美学习医学教育教学法。先后主持国家自然科学基金2项、国家重大新药创制专项1项、省级重点项目2项，参与多项国家级和省部级课题；发表文章90余篇，其中SCI收录40余篇；申报国家发明专利10项；获陕西省科技进步二等奖1项（第三完成人）。西安交通大学医学部名师，校级后备名师C类，校级教学卓越奖获得者；《药理学》国家级教学团队和国家级双语教学示范课程主要成员，国家级线上一流课程《药理学》MOOC的第二参与人；作为药理学教学团队带头人之一，获得西安交通大学第五届教学优秀团队奖；主编、副主编、参编教材教辅60余部，其中规划教材20余部；参与获得国家级、省部级和校级教学成果奖10项。兼任中国药理学会药理学教学与科普专业委员会委员、中国药理学会定量药理学专业委员会委员、中国药理学会肾脏药理学专业委员会委员、中国微循环学会微循环药物研究专业委员会委员、中国卫生健康思想政治工作促进会医学教育科研分会理事、陕西省药理学会常务理事、陕西省生理科学会常务理事、陕西省毒理学会常务理事等。

1.CD36介导GLP-1RA改善糖尿病非酒精性脂肪肝病的肠肝轴调控机制研究（2023-JC-ZD-47）陕西省自然科学基础研究计划重点项目 2023.1-2025.12 20 万

2.电压门控性钾通道在糖尿病认知功能障碍中的作用及机制研究（81471031） 国家自然科学基金 2015.1-2018.12 65万

3.蛋白多肽类药物缓释关键技术及产品研发（2013ZX09509106） “重大新药创制”科技重大专项 2013.1-2015.12 105万 / 327万

4.复方药物研发技术及复方胰岛素硒新药开发（2011KTCL03-20） 陕西省科技统筹项目 2012.1-2014.12 40万

5.载多西紫杉醇主动靶向PLGA纳米制剂的研发（xjj201443）西安交通大学基本科研业务费综合交叉面上项目 2014.1-2016.12 10万

1.He J#, Zhou Z#, Cheng G#, Li H, Tu J, Fan Z, Qiu X, Chen W, Chen Y, Li L, Li C, Li Z, Chen L*, Lu Q*. Neutrophil extracellular traps in the tumor microenvironment, metastasis, therapy, and beyond: advances, challenges, and perspectives. J Hematol Oncol. 2026 Apr 15. doi: 10.1186/s13045-026-01789-4. Epub ahead of print.

2.Lu Q, Zheng Q, Zhou Z, Chen Y, Chen Y, Chen W, Wang J, Guo R, Wu R, Chen L*. CGRP enhances the regeneration of bone defects by regulating bone marrow mesenchymal stem cells through promoting ANGPTL4 secretion by bone blood vessels. Adv Sci (Weinh). 2026, 13(14):e22295.

3.Shang D#, Zhou Z#, Shi R#, Wang Z#, Zhang P#, Peng F, Li H, Cheng G, Qin H, Xie Z, Xu Y, Zhou X, Chen W, Chen Y, Yang S, Chen L*, Lu Q*, Xu R*. Nanoparticle-based strategy in CAR-T cell immunotherapy: challenges, implications, and perspectives. Mol Cancer. 2025, 24:281.

4.Si R#, Zhao C#, Mo L#, Xu Z, Zong Y, Jia Z, Zhao W, Lu J, Xue X, Chen L*, Fu R*, Ren S*. A novel lipid microbubble targeting E-selectin for ultrasound molecular imaging of acute kidney injury in rats. Mol Pharm. 2025, 22(10):6163-6173.

5.Yan W, Cui X, Guo T, Liu N, Wang Z, Sun Y, Shang Y, Liu J, Zhu Y, Zhang Y, Chen L*. ALOX15 aggravates metabolic dysfunction-associated steatotic liver disease in mice with type 2 diabetes via activating the PPARγ/CD36 axis. Antioxid Redox Signal. 2025, 43(1-3):37-55.

6.Liu N, Sun Y, Liu J, Zhang Y, Yi X, Yan W, Cui X, Guo T, Zhao W, Han S, Ma W, Cao Y*, Chen L*. Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia. Apoptosis. 2025, 30(3-4):842-860.

7.Liu N, Cui X, Guo T, Wei X, Sun Y, Liu J, Zhang Y, Ma W, Yan W*, Chen L*. Baicalein ameliorates insulin resistance of HFD/STZ mice through activating PI3K/AKT signal pathway of liver and skeletal muscle in a GLP-1R-dependent manner. Antioxidants (Basel). 2024, 13(10):1246.

8.Zhu Y#, Huang X#, Deng Z, Bai T, Gao B, Xu C, Fu J, Zhao Y, Zhang Y, Zhang M, Zhang M*, Yang M*, Chen L*. Orally biomimetic metal-phenolic nanozyme with quadruple safeguards for intestinal homeostasis to ameliorate ulcerative colitis. J Nanobiotechnology. 2024, 22(1):545.

9.Liu N, Cui X, Yan W, Guo T, Wang Z, Wei X, Sun Y, Liu J, Xian C, Ma W*, Chen L*. Baicalein: A potential GLP-1R agonist improves cognitive disorder of diabetes through mitophagy enhancement. J Pharm Anal. 2024, 14(8):100968.

10.Luo Y, Li L, Hu Q, Zhang Z, Liu F, Peng Y, Zou Y, Chen L*. Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2. Int J Biochem Cell Biol, 2024, 169:106553.

11.Guo T, Yan W, Cui X, Liu N, Wei X, Sun Y, Fan K, Liu J, Zhu Y, Wang Z, Zhang Y*, Chen L*. Liraglutide attenuates type 2 diabetes mellitus-associated non-alcoholic fatty liver disease by activating AMPK/ACC signaling and inhibiting ferroptosis. Mol Med, 2023, 29:132.

12.Wang Z#, Cui X#, Yan W, Liu N, Shang J, Yi X, Guo T, Wei X, Sun Y, Hu H, Ma W*, Cui W*, Chen L*. Mollugin activates GLP-1R to improve cognitive dysfunction in type 2 diabetic mice. Life Sci, 2023, 331:122026.

13.Shang J#, Yan W#, Cui X, Ma W, Wang Z, Liu N, Yi X, Guo T, Wei X, Sun Y, Hu H, Cui W*, Chen L*. Schisandrin B, a potential GLP-1R agonist, exerts anti-diabetic effects through stimulating insulin secretion. Mol Cell Endocrinol, 2023, 577:112029.

14.Guo T, Yu Y, Yan W, Zhang M, Yi X, Liu N, Cui X, Wei X, Sun Y, Wang Z, Shang J, Cui W*, Chen L*. Erythropoietin ameliorates cognitive dysfunction in mice with type 2 diabetes mellitus via inhibiting iron overload and ferroptosis. Exp Neurol, 2023, 365:114414.

15.Yan W, Guo T, Liu N, Cui X, Wei X, Sun Y, Hu H, Yi X, Chen L*. Erythropoietin ameliorates cognitive deficits by improving hippocampal and synaptic damage in streptozotocin-induced diabetic mice. Cell Signal, 2023, 106:110614.

16.Luo Y, Chen J, Cui Y, Fang F, Zhang Z, Hu L, Chen X, Li Z, Li L*, Chen L*. Transcriptome-wide high-throughput m6A sequencing of differential m6A methylation Patterns in the decidual tissues from RSA patients. FASEB J, 2023, 37(3):e22802.